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Rajiv Gandhi University of Health Sciences, Karnataka
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V Year Pharm-D (II Year Pharm D Post Baccalaureate) / V Year Pharm-D Degree Examination – NOV 2017
Time: Three Hours
Max. Marks: 70 Marks
CLINICAL PHARMACOKINETICS & THERAPEUTIC DRUG MONITORING
Q.P. CODE: 2876 / 2892
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Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
- Discuss the importance of genetic polymorphism of cytochrome P-450 isozymes on drug metabolism with suitable examples.
- a) What are nomograms? Explain their applications in pharmacokinetic studies with examples. Give their advantages and disadvantages.
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b) Explain the sampling design used in population pharmacokinetic study - Enumerate and explain various factors in individualizing drug dosage forms
SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
- Explain the role of clinical pharmacist in TDM.
- Explain the influence of drug interaction on drug absorption with examples.
- Describe the methods of measurement of GFR and their significance.
- Give the reasons for conducting population pharmacokinetic study
- Explain the sigmoidal Emax model in PK/PD correlation.
- What is the creatinine clearance for a 25 year old male patient with a serum creatinine of 1mg/dL? The patient is 5 ft, 4inches in height and weighs 103 Kg.
- Explain various factors considered in the design of dosage regimen for obese patient.
- Define TDM. Discuss the indications for TDM of drugs
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SHORT ANSWERS 10 x 2 = 20 Marks
- Give the assumptions of compartment model.
- Give any two formulae for the calculation of paediatric dose.
- Calculate creatinine clearance for a 30 year old female patient with a serum creatinine value of 0.8 mg/dl. The patient is 5 ft 1 inch tall and weighs 69 kgs.
- Give Bayesian equation.
- Give the relationship between half-life and elimination rate constant.
- Write the protocol for TDM of a drug.
- Name the metabolic markers used in liver function test with their normal values.
- What do you understand by Goodness of Fit plot
- Define nomograms and tabulations.
- Give any two examples for clinically important genetic polymorphism of drug targets
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