Download RGUHS Pharm-D 1st Semester 2017 November 2877 Pharmaceutical Organic Chemistry Rs2 Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Pharm.D (Doctor of Pharmacy) 1st Semester 2017 November 2877 Pharmaceutical Organic Chemistry Rs2 Question Paper.

Rajiv Gandhi University of Health Sciences, Karnataka
I Year Pharm-D Degree Examination ? NOV 2017
Time: Three Hours Max. Marks: 70 Marks
PHARMACEUTICAL ORGANIC CHEMISTRY (RS2)
Q.P. CODE: 2877
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
1. Explain the mechanism, orientation and reactivity for the addition of hydrogen halides to alkenes.
2. Explain 1,2 and 1,4 additions in conjugated dienes with mechanism. Add a note on effect of
temperature.
3. Explain mechanism, kinetics and stereochemistry involved in the dehydrohalogenation of Alkyl
halides by a base.

SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
4. Define and classify free radicals. Describe orientation and stability of free radicals.
5. Give any five methods of preparation of cycloalkanes.
6. Discuss the mechanism, kinetics and stereochemistry of SN
1
reaction.
7. Describe nitration of benzene with mechanism.
8. What is benzoin condensation? Discuss the mechanism.
9. Discuss Cannizzaro reaction with mechanism.
10. Explain side chain halogenations in Alkyl Benzene. Add a note on resonance in Benzyl Radical.
11. Explain the stability in Conjugated Dienes.

SHORT ANSWERS 10 x 2 = 20 Marks
12. Write a short note on intermolecular forces.
13. Explain Lewis theory of acids and bases.
14. Write the structures of the following
a. 1, 3- Pentadiene b. Ethyl acetate
15. Explain the conditions which favor elimination over substitution.
16. Explain allylicrearangement with example.
17. Convert benzoic acid to methyl benzoate.
18. Compare the basicity among ammonia, ethylamine, tertiarybutylamine. Give reason.
19. How will you convert phenol to salicylic acid? Write reactions.
20. Give one example of oxidation and reduction reaction.
21. Give preparation and uses of aspirin.
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