Download RGUHS Pharm-D 1st Semester 2016 Nov-Dec 2854 Pharmaceutical Organic Chemistry Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Pharm.D (Doctor of Pharmacy) 1st Semester 2016 Nov-Dec 2854 Pharmaceutical Organic Chemistry Question Paper.

Rajiv Gandhi University of Health Sciences, Karnataka
I Year Pharm-D Examination ? NOV 2016

Time: Three Hours Max. Marks: 70 Marks

PHARMACEUTICAL ORGANIC CHEMISTRY

Q.P. CODE: 2854

Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
1. a) What are alkenes? Give the rules for their nomenclature with examples.
b) Explain the addition of carbenes to alkenes.
2. What is meant by orientation and reactivity on aromatic rings? Discuss the orientation effect in
nitrobenzene and chlorobenzene.
3. Explain SN
2
reactions with reference to
a) Mechanism b) Stereo chemistry c) Structure of substrate d) Role of solvents.

SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
4. Define dehydrohalogenation. Write the reactivity and orientation in E
1
reaction.
5. Explain the mechanism involved in
a) Cannizzaro?s reaction
b) Friedel-Craft?s acylations
6. Give the synthesis, assay and uses of Sachharin Sodium.
7. Explain the basicity of Amines.
8. Write a note on phase transfer catalysis.
9. Giving mechanisms explain the Markonikov?s rule and Anti-Markonikov?s rule.
10. Define acidity. Explain the effect of substituents on the acidity of the carboxylic acids.
11. Give the synthesis and uses of Aspirin. How it is tested for the presence of free Salicyllc acid?

SHORT ANSWERS 10 x 2 = 20 Marks
12. Define dipole moment. Why dipole moment of CCl
4
is zero?
13. What is Knoevengle?s reaction? Give one example.
14. Define protic and aprotic polar solvent with examples.
15. Write the structure of (a) Methyl 4-oxopentanoate (b) 5-Amino-3-hexanol.
16. What is optical isomerism? Give one example.
17. Why boiling point of the o-Aminophenol is lesser than the P-Aminophenol?
18. What is hyperconjugation? Give example.
19. Give the structure and uses of
a) Citric acid b) Tartaric acid
20. What is 1, 2-hydride shift? Give example.
21. Define free radicals. Give examples.

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