Download RGUHS (Rajiv Gandhi University of Health Sciences) Pharm.D (Doctor of Pharmacy) 4th Semester 2016 Nov-Dec 2888 Biopharmaceutics And Pharmacokinetics Question Paper.
Rajiv Gandhi University of Health Sciences, Karnataka
IV Year Pharm-D (Post Baccalaureate) Degree Examination ? NOV 2016
Time: Three Hours Max. Marks: 70 Marks
BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. CODE: 2888
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary.
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
1. Define AUC. Explain the various methods for determining the same.
2. Explain one compartment model with respect to extravascular administration.
3. Define Protein Binding. Explain its kinetics and significance in details.
SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
4. Explain the mechanisms of absorption in brief.
5. Explain the rat perfusion technique for determining the absorption.
6. Explain the study designs used for the conduct of bioavailability studies.
7. What are the advantages of compartmental models?
8. What do you understand by multi ? compartment models? What tissues or organs are grouped
under 1, 2 and 3 compartments?
9. Explain conjugation reactions in details.
10. What are the regulatory guidelines for bioavailability?
11. Explain MRT and how to calculate it in details?
SHORT ANSWERS 10 x 2 = 20 Marks
12. Define Ke and K.
13. Define Facilitated Transport.
14. Why do we model the data in pharmacokinetics?
15. Define pharmacokinetics.
16. What is gromerular filtration?
17. What is Ka? How is it determined?
18. Define organ clearance and give a formula for the same.
19. Name the membranes which act as barrier for drug absorption.
20. What is the effect of food on absorption of drug?
21. Enlist the factors affecting biotransformation.
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This post was last modified on 20 December 2019