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Rajiv Gandhi University of Health Sciences, Karnataka
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IV Year Pharm-D (Post Baccalaureate) Degree Examination – NOV 2016
Time: Three Hours
Max. Marks: 70 Marks
BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. CODE: 2888
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- Define AUC. Explain the various methods for determining the same.
- Explain one compartment model with respect to extravascular administration.
- Define Protein Binding. Explain its kinetics and significance in details.
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Explain the mechanisms of absorption in brief.
- Explain the rat perfusion technique for determining the absorption.
- Explain the study designs used for the conduct of bioavailability studies.
- What are the advantages of compartmental models?
- What do you understand by multi compartment models? What tissues or organs are grouped under 1, 2 and 3 compartments?
- Explain conjugation reactions in details.
- What are the regulatory guidelines for bioavailability?
- Explain MRT and how to calculate it in details?
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SHORT ANSWERS 10 x 2 = 20 Marks
- Define Ke and K.
- Define Facilitated Transport.
- Why do we model the data in pharmacokinetics?
- Define pharmacokinetics.
- What is glomerular filtration?
- What is Ka? How is it determined?
- Define organ clearance and give a formula for the same.
- Name the membranes which act as barrier for drug absorption.
- What is the effect of food on absorption of drug?
- Enlist the factors affecting biotransformation.
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