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Rajiv Gandhi University of Health Sciences, Karnataka
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I Year Pharma-D Examination – Mar 2013
Time: Three Hours
Max. Marks: 70 Marks
PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. CODE: 2854
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Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- a) Give an account on Markonikov's and Anti Markonikov's additions to alkenes, giving examples.
b) Explain the mechanism and orientation involved in the hydration of alkenes - Give the method of preparation and uses of the following
a) Benzyl benzoate b) Lactic acid c) Saccharin sodium d) Methyl salicylate e) Dimercaprol - a) Discuss the resonance and orbital descriptions of Allyl cation.
b) Explain hyperconjugation and its importance in the study of stability of carbocations and free radicals.
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
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- Discuss the mechanism of Friedel-Craft's alkylations in benzene. What are their limitations?
- Write a note on the acidity of carboxylic acids.
- Discuss the conditions that favour unimolecular substitution over bimolecular substitution in Alkyl halides.
- Write a note on Heat of hydrogenation and compare the stability of alkenes.
- Explain the concept of aromaticity and Huckel's rule with examples.
- Define and classify isomerism with examples.
- Write a note on Elimination Vs Substitution.
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SHORT ANSWERS 10 x 2 = 20 Marks
- Explain the orientation and rearrangements involved in E1 reactions.
- Draw the structural formula for the following:
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a)trans-1,2-dichloroethene b) 1-Penten-4-yne - Explain the term "Polarity of bonds".
- What is crossed Aldol condensation? Give the equation.
- How will you assay dimercaprol?
- Draw the structural formula for the following:
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a) 2-Methyl-2-butene b) 2,5-Dimethyl-2-hexene. - Arrange the free radicals in their order of stability.
a) Vinyl, CH2=CH b) Allyl, CH2=CH-CH2 c) Benzyl, C6H5-CH2 - Give the Lowry-Bronsted and Lewis theory of acid and base.
- Give the structure and uses of
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a) Chlorbutol b) Tartaric acid - Classify amines with examples and structures.
- Distinguish between intra and intermolecular hydrogen bonding. Give examples.
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