Download MBBS (Bachelor of Medicine, Bachelor of Surgery) Rajiv Gandhi University of Health Sciences 1024 Biochemistry Paper I 2022 March Previous Question Paper
QP CODE : 1024
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase -- I (CBME) Degree Examination - 05-Mar-2022
Time: Three Hours
Max. Marks: 100 Marks
BIOCHEMISTRY -- PAPER I (RS-4)
QP Code: 1024
(QP contains three pages)
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS
2 x 10 = 20 Marks
1. A 8 year old boy was brought to orthopaedic OPD with a complaint of abnormal gait for the
past 3 months. Clinical examination showed tenderness over Tibia.
Laboratory Investigation data revealed
Investigation
Patient report
Normal range
Serum Calcium
8.2 mg/d1
8.6-10.5 mg/di .
Serum Phosphate
2.3 mg/dl
2.3-4.5 mg/di
Serum Vitamin D
3 n. ml
8-55 n? ml
a. Name the vitamin D deficiency disorder in the above case
b. What is the RDA of vitamin D?
c Explain the formation of calcitriol
d. Describe the role of calcitriol in calcium homeostasis
2.
Explain glycogenolysis. Write the difference between Liver and Muscle glycogenolysis.
Mention the role of insulin and glucagon in glycogenolysls.
SHORT ESSAYS
8 x 5 = 40 Marks
3. A pregnant lady who visited primary health care centre for antenatal check-up with
complaints of tiredness and easy fatigability was found to be anemic. Peripheral smear
showed microcytic hypochromic anemia.
a. Name the mineral associated with the above disorder
b. Write the dietary sources and RDA of the above mineral
c. Write the biochemical functions of above mineral.
4. A 60 year old obese man, who underwent master health check-up was found to have mild
hepatomegaly with fatty liver changes.
a. What is fatty liver?
b. Enumerate the causes of fatty liver
c. Explain the role of lipotropic factors in preventing fatty liver,
5.
Mention blood buffers. Explain the role of Lungs in acid base balance.
6.
List five functions of phosphorous.
7. Describe steps in Ketogenesis, Mention two conditions associated with Ketonuria.
8.
What is chemiosmotic hypothesis? Explain how proton gradient is utilized for ATP
synthesis.
9, Describe competitive inhibition of enzymes with two examples.
10. Define Basal Metabolic Rate (BMR). Mention four factors affecting BMR.
Page 1 of 3
`4.
SHORT ANSWERS
10 x 3 = 30 Marks
11. Mention three functions of cholesterol.
12,
What is HbA1C (Glycated Hemoglobin)? Mention its significance.
13,
What are therapeutic enzymes? Give two examples with their therapeutic application.
14. What is facilitated diffusion? Give one example.
15, What Is the role of Anti Diuretic Hormone (ADH) in water balance? Name the disorder
associated with its deficiency.
16, What is Alkali reserve? List two causes of metabolic acidosis.
17.
What is Marasmus? List two features of Marasmus.
18.
Define Km. What is the significance of Km?
19.
Name three mucopolysaccharides and write their functions.
20.
Troponins are more specific cardiac marker compared to creatine kinase -- Justify. Multiple
Multiple Choice Questions
10 x 1 = 10 Marks
21 i) Galactosyl transferase is marker for
A. Cell membrane
B. Mitochondria
C. Lysosomes
D. Golgi complex
?
Osteogenesis imperfecta is due to defect in:
21 i )
A. Actin
B. Collagen
C. Ker atin
D. Crystallin
21 iii) Bile acid is derived from
A .
C h o l e s t e r o l
B . Glycerol
C . Fatty acids
D . Billirubin
21 iv Inulin is a polymer of
A. Glucose
B. Fr-uctose
C. Mannose
D. Galactose
21 v) Which of the following mineral is best known for antioxidant role?
A . C a l c i u m
B . I r o n
C . Phosphorus
D. Selenium
22 i) Positive nitrogen balance Is seen in
A. Pregnancy
B. Malnutrition
C. Chronic Illness
22 il) Enzymes synthesized In Inactive form Is called as
A. Coenzymes
B. Apoenzymes
C. Proenzymes
D. Lysozymes
22 III) Phospholipid deficiency In respiratory distress syndrome Is
A. Sphingomyelin
B. Phosphatidyl ethanolamine
C. Plasmalogen
D. Lecithin
? 22 iv) Administration of loop diuretics leads to
A. Metabolic acidosis
B.Metabolic alkalosis
C. Respiratory acidosis
D. Respiratory alkalosis
22 v) Hyponatremia Is seen in
A.Addison's disease
B. Cushing's disease
C. Primary hyperaldosteronism
D. Steroid therapy
This post was last modified on 22 May 2022