QP CODE: 1024
Rajiv Gandhi University of Health Sciences, Karnataka
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MBBS Phase I (CBME) Degree Examination - 05-Mar-2022
Time: Three Hours Max. Marks: 100 Marks
BIOCHEMISTRY — PAPER I (RS-4)
QP Code: 1024
(QP contains three pages)
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Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
2 x 10 = 20 Marks
LONG ESSAYS
- A 8 year old boy was brought to orthopaedic OPD with a complaint of abnormal gait for the past 3 months. Clinical examination showed tenderness over Tibia.
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Laboratory Investigation data revealed
Investigation Patient report Normal range Serum Calcium 8.2 mg/dl 8.6-10.5 mg/dl Serum Phosphate 2.3 mg/dl 2.3-4.5 mg/dl Serum Vitamin D 3 n. ml 8-55 n. ml - Name the vitamin D deficiency disorder in the above case
- What is the RDA of vitamin D?
- Explain the formation of calcitriol
- Describe the role of calcitriol in calcium homeostasis
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- Explain glycogenolysis. Write the difference between Liver and Muscle glycogenolysis. Mention the role of insulin and glucagon in glycogenolysis.
8 x 5 = 40 Marks
SHORT ESSAYS
- A pregnant lady who visited primary health care centre for antenatal check-up with complaints of tiredness and easy fatigability was found to be anemic. Peripheral smear showed microcytic hypochromic anemia.
- Name the mineral associated with the above disorder
- Write the dietary sources and RDA of the above mineral
- Write the biochemical functions of above mineral.
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- A 60 year old obese man, who underwent master health check-up was found to have mild hepatomegaly with fatty liver changes.
- What is fatty liver?
- Enumerate the causes of fatty liver
- Explain the role of lipotropic factors in preventing fatty liver,
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- Mention blood buffers. Explain the role of Lungs in acid base balance.
- List five functions of phosphorous.
- Describe steps in Ketogenesis, Mention two conditions associated with Ketonuria.
- What is chemiosmotic hypothesis? Explain how proton gradient is utilized for ATP synthesis.
- Describe competitive inhibition of enzymes with two examples.
- Define Basal Metabolic Rate (BMR). Mention four factors affecting BMR.
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10 x 3 = 30 Marks
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SHORT ANSWERS
- Mention three functions of cholesterol.
- What is HbA1C (Glycated Hemoglobin)? Mention its significance.
- What are therapeutic enzymes? Give two examples with their therapeutic application.
- What is facilitated diffusion? Give one example.
- What Is the role of Anti Diuretic Hormone (ADH) in water balance? Name the disorder associated with its deficiency.
- What is Alkali reserve? List two causes of metabolic acidosis.
- What is Marasmus? List two features of Marasmus.
- Define Km. What is the significance of Km?
- Name three mucopolysaccharides and write their functions.
- Troponins are more specific cardiac marker compared to creatine kinase - Justify. Multiple
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10 x 1 = 10 Marks
Multiple Choice Questions
- Galactosyl transferase is marker for
- Cell membrane
- Mitochondria
- Lysosomes
- Golgi complex
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- Osteogenesis imperfecta is due to defect in:
- Actin
- Collagen
- Keratin
- Crystallin
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- Bile acid is derived from
- Cholesterol
- Glycerol
- Fatty acids
- Billirubin
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- Inulin is a polymer of
- Glucose
- Fructose
- Mannose
- Galactose
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- Which of the following mineral is best known for antioxidant role?
- Calcium
- Iron
- Phosphorus
- Selenium
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- Positive nitrogen balance Is seen in
- Pregnancy
- Malnutrition
- Chronic Illness
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- Enzymes synthesized In Inactive form Is called as
- Coenzymes
- Apoenzymes
- Proenzymes
- Lysozymes
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- Phospholipid deficiency In respiratory distress syndrome Is
- Sphingomyelin
- Phosphatidyl ethanolamine
- Plasmalogen
- Lecithin
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- Administration of loop diuretics leads to
- Metabolic acidosis
- Metabolic alkalosis
- Respiratory acidosis
- Respiratory alkalosis
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- Hyponatremia Is seen in
- Addison's disease
- Cushing's disease
- Primary hyperaldosteronism
- Steroid therapy
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