RUHS
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPER I
Time: 3 hours
Max Marks: 100

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Date: 19-01-2022
Instructions: INSTRUCTIONS: Attempt all questions in
both sections: (Use separate answer book for each
section)
Section 1

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1. Fill in the blanks: (6)
a. The cyanide inhibits electron transport chain
enzyme _______
b. Thiamine level is best monitored in blood by level
of enzyme _______

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c. The group of proteins assisting in folding of other
proteins are _______
d. The most important source of reducing equivalents
for fatty acid synthesis in the liver is _______
e. The zinc containing protein in the saliva involved in

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taste sensation is _______
f. The deficient enzyme in Phenylketonuria is
_______
2. Choose the correct option in the following multiple
choice questions: (4)

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a. Congenital erythropoietic Porphyria has all the

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features, except:
a. Sensitivity to sun light
b. Reddish discoloration of urine
c. Erythrocyte porphyrin level elevated

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d. Inherited as Autosomal recessive trait
b. A lipoprotein inversely related to the incidence of
coronary arthrosclerosis is:
a. VLDL
b. IDL

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c. LDL
d. HDL
c. The most active form of vitamin D is:
a. 25-Hydroxycholecalciferol
b. 1,25 Dihydroxycholecalciferol

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c. 25-Dihydroxyergocalciferol
d. None
d. Anion gap is normal in:
a. Hyperchloremic metabolic acidosis
b. Diabetic ketoacidosis

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c. Lactic acidosis
d. Uremic acidosis
3. A 55 year old man complained severe pain in the
joints. He has a non-vegetarian and consumed
alcohol occasionally. On examination I st

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metatarsophalangeal joint (15) was red and swollen.
The significant finding of blood investigation was uric
acid = 12 mg/dl. X-ray of foot did not show any bony
of soft tissue anomaly.
a. What is the probable diagnosis and suggest its

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cause?
b. What can be the enzyme defect in this disease?

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c. Which investigation is to be performed for
confirmation of diagnosis?
d. What are the risk factors for this diseases?

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e. What is the treatment?
4. Write short notes on (Any five): (10)
a. Regulation of glycogenesis.
b. Lipotropic Factors
c. Vitamin E as an antioxidant.

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d. Wilson's diseases.
e. Metabolic alkalosis.
f. Essential fatty acids.
5. Explain briefly (Any three); (15)
a. Phenylketonuria

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b. Diagnostic use of isoenzymes.
c. Electron transport chain and its inhibitors.
Section 2
1. Describe Ketogenesis and its regulation. What are the
salient features of ketosis? Explain metabolism of

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ketone bodies in starvation and uncontrolled diabetes
(20) mellitus.
2. Explain why (Any five): (10)
a. Person suffering from diabetes mellitus is more
prone to develop cataract.

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b. Bleeding gum is seen in scurvy.
c. HDL is considered as a good cholesterol.
d. Mental retardation is seen in phenylketonurics.
e. Amino acids are amphoteric in nature.
f. Fluoride prevents the development of dental caries.

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3. Explain briefly (Any four): (20)

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a. Glycogen storage diseases.
b. Role of folic acid in one-carbon metabolism.
c. Arterial blood gas (ABG) analyzer.
d. Transamination

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e. Homeostasis of calcium.
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