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Download RUHS MBBS 1st Year Physiology Paper I March 2023 Question Paper

Download RUHS (Rajasthan University for Health Sciences) MBBS (Bachelor of Medicine and Bachelor of Surgery) 1st Year (First Year) Physiology Paper I March 2023 Previous Question Paper

This post was last modified on 22 September 2025

RUHS
First Year MBBS Examination
I MBBS PHYSIOLOGY PAPER I
Time: 3 hours Max Marks: 100
Date: 31-03-2023

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Instructions: INSTRUCTIONS: Attempt all
questions in both sections: (Use separate
answer book for each section)
Section 1
1. Fill in the blanks: (6)

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a. Sodium enters the cell during the upstroke
of the action potential and the major
mechanism for removal and extrusion of
Na+ from the cell in this instance is
___________.

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b. The substance that contributes maximally
to osmolality inside the cell is
___________.

c. The phase of action potential caused by
inactivation of Na+ channels in a nerve

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axon is known as ___________.
d. ___________. is the sensory system
where the transducer and spike generator
are located on the same cell.
e. he infant condition (as observed by

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parents) of ___________. is most closely
related to Slow-Wave Sleep (SWS).
f. Multiple sclerosis is a disease that attacks
the ___________. of neurones in the
Central Nervous System (CNS).

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2. Choose the correct option in the following
multiple choice questions: (4)
a. A man falls into deep sleep with one arm
under his head. After awakening the arm
is paralyzed but tingling sensation and

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pain sensation persists. This loss of motor
function without the loss of sensory
function is due to; a) A Fibers are more
susceptible to hypoxia than B Fibers. b) A
Fibers are more sensitive to pressure than

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C Fibers. c) C Fibers are more sensitive to
pressure than A Fibers. d) Sensory Nerves
are nearer bone and hence affected by
Pressure.
b. When a normally innervated skeletal

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muscle is stretched the initial response is
contraction, with increase in the stretch
sudden relaxation occurs because of; a)
Decrease in Gamma Efferent Discharge.
b) Inhibition of the Discharge from

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Annulospiral Endings of Afferent Nerve
Fibers. c) Decreased activity of afferent
nerve fibers from Golgi Tendon Organs. d)
Increased activity of afferent nerve fibers
from Golgi Tendon Organs

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c. Sweat in patients acclimatised to hot
weather (as compared to patients in a
temperature climate) contains less Na+
because: a) Takes longer for Na+ to be
transported through sweat ducts. b)

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Aldosterone effect, causing a reduction in
Na+ in sweat. c) Increased intake of water
causing a reduction in Na concentration.

d) None of the above.
d. Which of the following is a feature of both

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the stretch reflex and the withdrawal
reflex? a) Irradiation. b) After-discharge. c)
Small afferent fibres. d) Reciprocal
innervation.
3. Clinical Case Study (Clinical Case

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Description): A 30-year-old woman, with a
28-day menstrual cycle, consults her
gynaecologist for various forms of barrier
(15) methods, the patient now wants to.
contraception. On having tried 'the pill' or an

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'injection'. She further informs that she and
her husband travel a lot and often forgets to
take her prescribed antibiotics. From the
cafeteria approach, the woman decides to try
a long-acting depot injection of progesterone

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hormone, medroxyprogesterone (depo-
progesterone). She is given the injection and
instructed to follow up in 3 months for the
next injection. Answer the following questions
with diagrams wherever necessary. a) How

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do injectable hormones or hormone pills

provide contraception? b) Give the location
of receptor for progesterone and enumerate
mechanism of action of progesterone at
cellular level. c) Define Exocytosis and

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explain the features of Exocytosis. d)
Describe cellular physiology of second
messenger system. c) Describe the various
neurophysiological phases of a 28-day
menstrual cycle of the said patient.

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4. Write short notes on (Any five): (10)
a. Humoral Immunity
b. Rheobase and Chronaxie
c. Metabotropic receptors
d. Pituitary dwarf (C2-675)

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e. Myoglobin
f. Receptor potential (C1-38)
5. Explain briefly (Any three): (15)
a. Heat stroke
b. Compound action potential

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c. Servo-controller mechanisms of glucose

homeostasis
d. Gibbs-Donnan equilibrium

Section 2
1. Define Diabetes Mellitus. Discuss in detail

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the physiological axes of glucose
homeostasis and give the rationale of
management profile of life style modifications
in (20) Type 2 Diabetes Mellitus (T2DM).
2. What will happen and why (Any fivc): (10)

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a. Repeated stimulation of a skeletal muscle
fibre result in sustained contraction
leading to increased tension (Tetanus).
b. A 38-year-old woman with myasthenia
gravis notes an increase in muscle

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strength on treatment with neostigmine, an
acetyl cholinesterase inhibitor.
c. Elevated K+ concentration causes severe
muscle weakness.
d. Patient with Cushing's Disease has hyper-

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pigmentation.
e. Oral glucose is more effective that
intravenous glucose in releasing
endogenous insulin.

f. The serum T3 levels are reduced in

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starvation.
3. Explain briefly (Any four): (20)
a. Type I skeletal Muscle Fibers
b. Myopia (C2-1105)
c. Functions of middle ear. (C2-1075)

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d. Neural circuitry and functions of basal
ganglia
e. Neurophysiology of sleep
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***

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