RUHS
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPER I
Time: 3 hours
Marks:

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100
Date: 12-04-2023
Instructions: INSTRUCTIONS: Attempt all
questions in both sections: (Use separate
answer book for each section)

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Section 1
1. Fill in the blanks: (6)
a. Amino acid playing role in O transport by
haemoglobin
b. Most common protein serum is

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c. Lipoprotein involved in transfer of lipids from
liver to peripheral tissues is
d. Vitamin synthesized from tryptophan is
e. Isoenzyme form of creatine kinase used for
diagnosis of myocardial infarction is

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f. Protein responsible for storage of iron is

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2. Choose the correct option in the following
multiple choice questions: (4)
a. Which of the following is not a part of PDH
complex;

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i. Pyruvate dehydrogenase
ii. Dihydrolipoyl transacetylase
iii. Dihydrolipoyl decarboxylase
iv. Dihydrolipoyl dehydrogenase
b. All are categorized as uncouplers except

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i. Thermogenin
ii. Thyroxine
iii. 2, 4 dinitrophenol
iv. Carboxin
c. All are components of glutathione except:

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i. Glutamate
ii. Cysteine
iii. Methionine
iv. Glycine
d. Metal with antioxidant action in glutathione

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peroxidase is;
i. Copper
ii. Selenium
iii. Magnesium
iv. Zinc

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3. A 3 year old boy presented with hypotonia,

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mental retardation, developmental delay,
irritability and self-mutilating behavior. The
serum uric acid was 9mg/dL. a) (15)
a. What is the probable diagnosis?

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b. What is the biochemical basis of this
condition?
c. What is the inheritance of this disorder?
d. What is the cause of mental retardation in
this condition?

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e. What is the management of hyperuricemia?
4. Write short notes on (Any five): (10)
a. Cori's cycle.
b. Bicarbonate buffer system.
c. HMG CoA reductase inhibitors.

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d. Functions of Vitamin-E.
e. Phenylketonuria (A.352)
f. Galactosemia (A.278)
5. Explain briefly (Any three): (15)
a. Transamination (A. 333)

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b. Regulation of glycogenolysis.
c. Gout.
d. Ceruloplasmin.

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Section 2
6. Enumerate ketone bodies. Explain the

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reactions leading to production of ketone bodies.
What is the fate of ketone bodies? (20)
7. Explain Why: (10)
a. Skeletal muscle glycogen doesn't contribute
to blood glucose.

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b. Vitamin -C can't be synthesized by humans.
c. Some antimalarials cause hemolysis in G6-
PD deficiency.
d. Myoglobin can't be used for transport of
oxygen in blood.

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e. Vitamin - D is considered as hormone.
8. Explain briefly (Any four): (20)
a. Metabolic acidosis and its compensation.
b. Salvage pathway. (A.393)
c. Hypocalcaemia-causes and manifestation.

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d. HDL cycle.
e. Competitive inhibition (A.94)
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