First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPER II
Time: 3 hours Max Marks: 100
Date: 13-04-2023
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Instructions: INSTRUCTIONS: Attempt allquestions in both sections: (Use separate
answer book for each section)
Section 1
1. Fill in the blanks: (6)
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a. The most common amino acid present incollagen is, _______
b. Limiting amino acid in pulses is _________
c. Phase - I xenobiotic metabolism
hydroxylation reactions are often catalyzed
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by group of enzymes called _________d. Urobilinogen is absent from urine in
_________ jaundice.
e. Hybridoma cell can be used to produce
_________ antibodies
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f. Xeroderma pigmentosum results from adefect in the _________ repair system.
2. Choose the correct option in the following
multiple choice questions: (4)
a. Which of the following is the best index of
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nutritive value of a protein?a. Biological value
b. Protein energy ratio
c. Net protein utilization
d. Net dietary protein value
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b. Which among the following is proteincoding RNA?
a. mRNA
b. tRNA
c. rRNA
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d. SIRNAc. Antibody that can cross protein to protect
foetus:
a. IgA
b. LGb
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c. IgDd. LGm
d. Increased ALP (Alkaline phosphatase) in
jaundice;
a. Liver damage -b
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b. Biliary obstructionc. Hemolysis
d. Viral infection
3. Two brother one aged 3 years and other
aged 2 years present to OPD for complaint of
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swelling over the body with protrudedabdomen. They belong to poor family. (15)
Family is mainly surviving on rice as their
staple meal with no access to dal and fruits or
vegetables. On examination, both children
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were lethargic, abdomen was noticeablyenlarged. Lower limbs showed pitting pedal
edema with scaly peeling of skin at certain
places. Hair examination revealed bands of
hypo pigmentation. Blood investigation
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revealed hypoalbuminemia in both thechildren.
a. Comment on the above diagnosis?
b. Explain the biochemical basis of clinical
symptoms & sign?
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c. How is the protein energy malnutrition(PEM) classified?
d. What is the difference between marasmus
and kwashiorkor?
e. What is the line of management in such
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cases?4. Write short notes on: (10)
a. Proto oncogene.
b. Inhibitors of replication in both prokaryotes
and eukaryotes.
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c. Diagnostic uses of PCR.d. Tumor markers with associated cancers.
e. Functions of immunoglobulins.
5. Explain briefly (Any three): (15)
a. Process of detoxification.
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b. Biochemical basis of monoclonalantibodies in cancer therapy.
c. Mechanism of DNA repair.
d. Creatinine clearance.
Section 2
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6. Explain the mechanism of transcription?How it is regulated? Mention inhibitors of
transcription (20)
7. Explain Why (Any five): (10)
a. Glutathione is an important mediator for
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detoxification of toxic material in I humans.b. Yeast artificial chromosome can act as
high capacity vector in DNA cloning.
c. Serum creatinine is better indicator than
serum urea for renal function test.
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d. Excessive carbohydrate consumption leadsto obesity.
e. A singlet - RNA can recognize more than
one codon.
f. Ps oncosuppressor gene prevents the
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development of cancer.
8. Explain briefly (Any four): (20)
a. Balanced diet (A.513)
b. Glomerular filtration rate.
c. Enzymes used as liver function test.
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d. Glycemic index.e. Northern blot technique.
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