RUHS
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPERI
Time: 3 hours Max Marks: 100
Date: 25-01-2023

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Instructions: INSTRUCTIONS: Attempt all
questions in both sections: (Use separate
answer book for each section)
Section 1
1. Fill in the blanks: (6)

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a. Lipoprotein responsible for reverse
cholesterol transport is
____________________.
b. Secondary structure present in collagen
protein ____________________.

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c. Low Km value indicates
____________________ affinity between
enzyme and substrate.
d. Chemical name of calcitriol is
____________________.

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e. Nitric oxide is synthesized from
____________________ amino acid.

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f. Type of bilirubin increased in obstructive
jaundice is ____________________.
2. Choose the correct option in the following

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multiple choice questions: (4)
a. Which type of inhibition Warfarin has on
vitamin K dependent carboxylase?
a) Competitive
b) Non - competitive

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c) Allosteric
d) Suicidal
b. Polysaccharide does not give colour with
iodine test:
a) Starch

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b) Dextrin
c) Cellulose
d) Glycogen
c. Von - Gierke's disease is characterized by all
except:

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a) Lactic acidosis
b) Hyperglycemia
c) Hyper uricemia
d) Hyperlipidemia
d. Complex of electron transport chain not

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functions as proton pump:
a) Complex I
b) Complex II

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c) Complex III
d) Complex IV

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3. A 66 years age obese male had severe chest
pain in the morning after doing exercise. He
describe pain as retrosternal and radiating to
the left arm. On investigation (15) serum
troponin I was raised. He had complaint of

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dyspnoca and intermittent palpitations. Based
on this history answer:
a. What is probable diagnosis?
b. What other investigations are to be
performed for diagnosis?

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c. What is the role of isoenzymes in diagnosis
of this case?
d. What is flipped pattern?
e. What are various risk factors for this
disease?

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4. Write short notes on (Any five) (10)
a. Ferritin
b. Anion gap (A.482)
c. Atherosclerosis. (A.317)
d. Uncouplers

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e. Denaturation of proteins
f. Transaminases.

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5. Explain briefly (Any three) (15)
a. Chemiosmotic theory
b. Krebs Henseleit cycle.

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c. Fate of Acetyl COA (A.253)
d. Functions of electrolytes.

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Section 2
6. Discuss the reactions of cycle with its
energetic. Suggest role of vitamins in Krebs

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cycle. (20)
7. Explain Why (Any Five ) (10)
a. Liver cannot utilize ketone bodies.
b. Insulin is given to diabetics by subcutaneous
route

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c. Eating raw eggs causes biotin deficiency.
d. Vitamin C is not synthesized in starvation.
e. Ketoacidosis is observed in starvation.
f. Ammonia is toxic to brain. (A.336)
8. Explain briefly (Any Four ) (20)

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a. Products obtained from Glycine amino acid.
(A.344)
b. Biochemical functions and deficiency
manifestations of Vitamin A.
c. Diagnostic significance of enzyme

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d. Differential diagnosis of jaundice.
e. Gluconeogenesis.
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Document Outline

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