RUHS
First Year MBBS Examination
I MBBS PHYSIOLOGY PAPER I
Time: 3 hours
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Max Marks: 100Instructions: INSTRUCTIONS: Attempt all
questions in both sections: (Use separate
answer book for each section)
Section 1
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1. Fill in the blanks: (6)a. Most accurate method to measure
extracellular fluid volume (ECFV) is by
using,__________
b. The degenerative changes occurring in the
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distal segment of the axon arecalled,__________
c. __________ part of the brain, first of all
manifests the hypoglycemic symptoms.
d. Mechanism of action of intrauterine
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contraceptive device (IUCD) is based on__________
e. Sensory aphasia is produced due to the
lesion in __________ area of the cerebral
hemisphere.
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f. Short-sightedness can be corrected byusing __________ glasses.
2. Choose the correct option in the following
multiple choice questions: (4)
a. The rod receptor potential differs from
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other sensory receptors because it isassociated with a) Depolarization. b)
Decreased negativity. c) Hyperpolarization.
d) Either hyperpolarization or
depolarization.
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b. Sertoli cells in the testis have receptors fora) LH. b) Inhibin. c) FSH. d) GnRH.
c. Sweet taste is mediated by a)
Guanylcyclase. b) Tyrosine kinase. c)
Epithelial Na* chain. d) G protein
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gustducin.d. There is mid-cycle shift in the basal body
temperature (BBT) after ovulation in
women. This is caused by a) Progesterone.
b) LH-peak. c) Oestradiol. d) FSH-peak.
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3. A 2-year old male child with a chief complaintof failure to appropriately gain weight despite
right adequate caloric intake, came to the
paediatric OPD. On examination there was
swelling in his right leg along with thickening
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of the left wrist and both the ankles. Later onhe was diagnosed to have rickets. Answer the
following questions-
a. Describe synthesis of Vitamin D.
b. Describe pathophysiology of development
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of rickets.c. Describe the role of Vitamin D in bone. (15)
4. Write short notes on (Any five): (10)
a. Blood-testis barrier
b. Renshaw cell inhibition
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c. Molecular motorsd. Facilitated diffusion
e. Neurotrophins
f. Recruitment of motor units
5. Explain briefly (Any three): (15)
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a. Fight or flight reactionsb. Role of calcium in smooth muscle
contraction
c. Physiological changes that occur in d
different organ system due to ageing
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d. Genesis of resting membrane potential(RMP) (C-36)
Section 2
6. Describe the principal connections and
functions of basal ganglia. Describe briefly
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about Parkinson's disease. Add a note onother dysfunctions of basal ganglia. (20)
7. Explain why (Any five): (10)
a. There is polyphagia in diabetes mellitus.
b. Genetic sex is determined entirely by the
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sperm.c. Osteoporosis is common in women after
menopause.
d. Digitalis is used in the treatment of heart
failure.
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e. A patient who lost his leg in an accidentfeels proprioceptive sensations and
intolerable pain in the amputated limb that
no longer exists.
f. Radiologist wears red goggles when in
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bright light.8. Explain briefly (Any four): (20)
a. Neuromuscular blockers)
b. Role of hypothalamus in regulation of body
temperature
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c. Sodium potassium pumpd. Intercellular junctions
e. lonic basis of different phases of action
potential in nerve
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