RUHS
Date: 30-11-2024
Second Year MBBS Examination
II MBBS PHARMACOLOGY PAPER I
Time: 3 hours
Instructions: INSTRUCTIONS: Attempt all
questions in both sections: (Use separate
answer book for each section)
Section 1
a. Intra-venous administration of drugs ensures
________ bio availability.
b. Myasthenia gravis is associated with the
production of ________ anti-body that binds to
c. 5-HT is formed from ________
d. An ultra-short acting thiobarbiturate thiopental
induces anaesthesia rapidly due to its
high________ solubility.
treatment of migraine is ________
f. A recombinant humanized monoclonal anti-
body________ is not suitable for acute attacks
of asthma.
Questions): 4x1=04
a. Actions of Pilocarpine include the following
except: a) Sweating b) Salivation c) Myosis d)
Cycloplegia
Metabotropic receptor b) lonic receptor c)
Kinase linked receptor d) Nuclear receptor
c. Selegeline is an example of: a) COMT Inhibitor
b) Peripheral decarboxylase inhibitor c)
inhibitor
d. Drug of choice for treatment of absence
seizures is: a) Phenytoin b) Valproate c)
Ethosuximide d) Carbamazepine
history of pain the epigastrium and the right
hypochondrium. He revealed that the pain
radiates to the back and is relieved on taking
food. He takes meals twice a day. On
epigastrium. 1. What could be the probable
diagnosis? What investigation would you
suggest? 2. What treatment would you
suggest? Write in detail. 3. Any other
instructions you would like to give. 4. Mention
the side effects of the drugs you are giving him.
4. Write short notes on (Any five):
a. Orphan drug
b. Transdermal therapeutic system (TTS)
d. Adverse effects of Barbiturates
e. Therapeutic uses of Neostigmine
f. Autonomy in patient care
5. Explain (Any three):
pharmacologic agent?
b. Why the phenomenon of Tachyphylaxis
occurs, with suitable examples?
c. Why colchicine is used in the management of
d. Why halothane is contra indicated in patients
with Pheochromocytoma?
Section 2
6.What are Anti-cholinesterases (AChE)?
organo-phosphate poisoning in detail.
7. Write short notes on (Any five): 5 x 2 =10
a. Status epilepticus
b. Uses of opioids
d. Dose-response curve
e. Double blind trials
f. Effect of urine pH on drug elimination
8. Explain briefly: 4 x 5=20
effect of levodopa.
b. Benzodiazepines are preferred over
barbiturates as hypnotic drugs.
c. Treatment of constipation.
***
Date: 30-11-2024
Second Year MBBS Examination
II MBBS PHARMACOLOGY PAPER I
Time: 3 hours
--- Content provided by FirstRanker.com ---
Max Marks: 100Instructions: INSTRUCTIONS: Attempt all
questions in both sections: (Use separate
answer book for each section)
Section 1
--- Content provided by FirstRanker.com ---
1. Fill in the blanks: 6x1=06a. Intra-venous administration of drugs ensures
________ bio availability.
b. Myasthenia gravis is associated with the
production of ________ anti-body that binds to
--- Content provided by FirstRanker.com ---
Ach receptorsc. 5-HT is formed from ________
d. An ultra-short acting thiobarbiturate thiopental
induces anaesthesia rapidly due to its
high________ solubility.
--- Content provided by FirstRanker.com ---
e. Anti-depressant that can be used for thetreatment of migraine is ________
f. A recombinant humanized monoclonal anti-
body________ is not suitable for acute attacks
of asthma.
--- Content provided by FirstRanker.com ---
2. Answer the followings (Multiple ChoiceQuestions): 4x1=04
a. Actions of Pilocarpine include the following
except: a) Sweating b) Salivation c) Myosis d)
Cycloplegia
--- Content provided by FirstRanker.com ---
b. G Protein Coupled Receptor (GPCR) is aa)Metabotropic receptor b) lonic receptor c)
Kinase linked receptor d) Nuclear receptor
c. Selegeline is an example of: a) COMT Inhibitor
b) Peripheral decarboxylase inhibitor c)
--- Content provided by FirstRanker.com ---
Peripheral carboxylase inhibitor d) MAOinhibitor
d. Drug of choice for treatment of absence
seizures is: a) Phenytoin b) Valproate c)
Ethosuximide d) Carbamazepine
--- Content provided by FirstRanker.com ---
3.A 45 year old man visited the OPD withhistory of pain the epigastrium and the right
hypochondrium. He revealed that the pain
radiates to the back and is relieved on taking
food. He takes meals twice a day. On
--- Content provided by FirstRanker.com ---
examination there is tenderness in theepigastrium. 1. What could be the probable
diagnosis? What investigation would you
suggest? 2. What treatment would you
suggest? Write in detail. 3. Any other
--- Content provided by FirstRanker.com ---
instructions you would like to give. 4. Mention
the side effects of the drugs you are giving him.
4. Write short notes on (Any five):
a. Orphan drug
b. Transdermal therapeutic system (TTS)
--- Content provided by FirstRanker.com ---
c. Centrally acting muscle relaxantsd. Adverse effects of Barbiturates
e. Therapeutic uses of Neostigmine
f. Autonomy in patient care
5. Explain (Any three):
--- Content provided by FirstRanker.com ---
a. Why acetyl choline cannot be used aspharmacologic agent?
b. Why the phenomenon of Tachyphylaxis
occurs, with suitable examples?
c. Why colchicine is used in the management of
--- Content provided by FirstRanker.com ---
acute gout?d. Why halothane is contra indicated in patients
with Pheochromocytoma?
Section 2
6.What are Anti-cholinesterases (AChE)?
--- Content provided by FirstRanker.com ---
Describe the diagnosis and treatment oforgano-phosphate poisoning in detail.
7. Write short notes on (Any five): 5 x 2 =10
a. Status epilepticus
b. Uses of opioids
--- Content provided by FirstRanker.com ---
c. Mixed order kineticsd. Dose-response curve
e. Double blind trials
f. Effect of urine pH on drug elimination
8. Explain briefly: 4 x 5=20
--- Content provided by FirstRanker.com ---
a. Pyridoxine attenuates the Antiparkinsonianeffect of levodopa.
b. Benzodiazepines are preferred over
barbiturates as hypnotic drugs.
c. Treatment of constipation.
--- Content provided by FirstRanker.com ---
d. Methyl alcohol poisoning.***