PHARMD 0122] JANUARY 2022 Sub. Code: 3804
(OCTOBER 2021 EXAM SESSION)
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PHARM. ‘D’ DEGREE EXAMINATION
FIRST YEAR (2009-2010 Regulation)
PAPER IV - PHARMACEUTICAL ORGANIC CHEMISTRY
O.P. Code : 383804
Time : Three hours Answer ALL Questions Maximum : 70 Marks
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Elaborate on: (4 x 10 =40)
- Discuss on the mechanism, kinetics and stereo chemistry of Aliphatic nucleophilic substitution with suitable examples.
- Elaborate on the free radical halogenations reaction in alkenes. Compare free radical substitution with free radical addition.
- Specify on the mechanism and ionization of carboxylic acids. Add a note on the conversion of acid to amide and ester.
- Explain the following reactions:
- Fries Rearrangement.
- Reimer - Tiemann reaction.
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Write notes on: (6x5=30)
- Briefly write on the polarity of molecules and bonds.
- Explain how the nomenclature of the organic compound is expressed in case of aldehydes and dienes.
- What are the various organic redox reactions? Give a note on any one reaction.
- Give the preparation, assay and use of Lactic acid and Ethyl benzoate.
- Jot down on the basicity of amines.
- What is resonance and hyperconjugation? Add salient features on the resonance stabilization of allyl radicals.
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