Download Pharm D 3rd Year 2012 October 383814 Pharmaceutical Analysis Question Paper

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Sub. Code: 3814

DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION

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THIRD YEAR

PAPER II - PHARMACEUTICAL ANALYSIS

O.P. Code: 383814

Time: Three Hours

Maximum: 100 marks

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Answer ALL questions in the same order

1. Elaborate on :

   1. Explain the working with the help of a neat, labeled, schematic block diagram of a HPLC and describes its operational modalities briefly. Write the advantages and classification based on mode of separation of HPLC.

      Pages Time Marks

      (Max.) (Max.) (Max.)

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      17 40 min. 20

   2. Discuss the underlying principle of Atomic Absorption Spectrometry (AAS). Describe the various components that are essentially involved in double beam AAS with help of a schematic diagram. How do the following three types of interferences affect the atomic absorption spectroscopic methods (a) Spectral interferences (b) Chemical interferences (c) Ionisation interferences.

      17 40 min. 20

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2. Write notes on :

   1. Express Beer-Lambert’s Law. Write its limitation, application and deviation.

      4 10min. 6

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   2. a) Flame Ionization detectors.

      b) What are the various factors affect the separation of compounds in column chromatography.

      4 10min. 6

   3. Discuss the typical conductrometric titration curves obtained in conductrometric-method of analysis and examine them critically with appropriate examples .

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      4 10min. 6

   4. Write a note on: (a) Glass electrodes (b) Dropping Mercury Electrons (DME).

      4 10min. 6

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   5. Spectrophometric titration.

      4 10min. 6

   6. Sample handling in IR spectroscopy.

      4 10min. 6

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   7. What is Fluorescence? What are the various factors affecting the fluorescence intensity?

      4 10min. 6

   8. What is mass spectrum? Write its principle and different type of ions produced in that.

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      4 10min. 6

   9. Write a note on DSC.

      4 10min. 6

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   10. What is validation? Give a brief account of validation of analytical methods

       4 10min 6

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