Download Pharm D 3rd Year 2012 October 383817 Medicinal Chemistry Question Paper

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[LB 817] OCTOBER 2012 Sub. Code: 3817

DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION

THIRD YEAR

PAPER V ? MEDICINAL CHEMISTRY

Q.P. Code: 383817

Time: Three Hours











Maximum: 100 marks

Answer ALL questions in the same orde

I. Elaborate on :













Pages Time Marks



















(Max.) (Max.) (Max.)

1. Write the classification of Antineoplastic agents and explain in 17 40 min. 20

detail their chemistry with suitable examples along with

mechanism of action. Synthesize any two drugs under various

classes.



2. Classify cardiovascular agents.

Discuss on antihyperensives and antiarrythmics in detail.

17 40 min. 20

II. Write notes on:

1. Write the chemistry, structures and synthesis of any one

drug under the category of anthelmintics.





4 10 min. 6

2. Discuss on oral hypoglycemic agents.







4 10 min. 6

3. Brief out on computer aided drug design.







4 10 min. 6

4. Classify broad spectrum pencillins and write the mechanism

of action.















4 10 min. 6

5. Brief out on prodrugs and their applications.





4 10 min. 6

6. Write on thiazides and osmotic diuretics.







4 10 min. 6

7. Give a short account on anti thyroid hormones.





4 10 min. 6

8. Write on the electronic, lipophilic and steric parameters.

4 10 min. 6

9. What is the concept of antisense molecules?





4 10 min. 6

10. Discuss on macrolides.











4 10 min. 6



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