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[LC 814] APRIL 2013 Sub. Code: 3814
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DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER II - PHARMACEUTICAL ANALYSIS
Q.P. Code: 383814
Time: Three Hours Maximum: 100 marks
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Answer All questions
-  Elaborate on: (2x20=40) - Explain the working and components of gas chromatograph with help of a neat, labeled, schematic block diagram. Write a note on classification, principle, factors influencing the separation and criteria to perform the Gas chromatography.
-  a) Draw an UV-Visible double beam spectrophotometer with a neat, labeled, block diagram and explain its each component operational mode. 
 b) Why a double beam spectrophotometer gives more precise, reliable and reproducible results in comparison to a single beam spectrophotometer?
 c) What are the factors influencing the absorption of radiant energy?
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-  Write notes on: (10 x 6 =60) - Give a brief and comprehensive account of application of conductometry?
- State Beer-Lambert’s law. Derive it Write its-application, deviation and limitation.
- Discuss the underlying principle and interference of atomic absorption spectrometry.
- Name the detectors used in HPLC. Discuss anyone of them.
- Differentiate validation and calibration. Give a brief account of validation of analytical methods.
- Explain the theory and procedure of DSC.
-  Discuss the fundamental theory of mass spectroscopy. 
 What are the different ions produced in mass spectrum?
-  What is quenching? What are different type of quenching? --- Content provided by FirstRanker.com --- Write a note on factors affecting the fluorescence intensity.
- Explain the various method of sample handling in IR-Spectroscopy.
-  Give a brief account of : 
 a) Indicator electrode, b) Polarizable electrode, c) Spectrophotometric titration.
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