Download Pharm D 3rd Year 2013 October 383817 Medicinal Chemistry Question Paper

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[LD 817] OCTOBER 2013 Sub. Code: 3817

DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION

THIRD YEAR

PAPER V ? MEDICINAL CHEMISTRY

Q.P. Code: 383817

Time: Three Hours











Maximum: 70 marks

Answer All questions

I. Elaborate on:

















(2 x 20 = 40)

1. What are Tetracyclines and Classify with structural examples for each?

Discuss briefly SAR, Chemistry and mechanism action of Tetracyclines.

2. a) Classify antitubercular agents.

b) Give synthesis of any two drugs with mechanism of action.

c) Explain briefly antiprotozoal agents.

II. Write notes on:











(10 x 3 = 30)

1. What is prodrug? Explain the types of pro drugs with suitable examples

2. Give a method of synthesis of:

(i) Hexachlorphene

(ii) Halazone

3. Classify anti fungal agents and give their mechanism of action

4. What are urinary tract anti-infectives? Classify them with suitable examples

5. Give the structure and uses of

(i) INH (ii) Ehionamide (iii) Pyrazinamide

6. Explain the mechanism of action of Mitronidazole

7. Write a short note on HIV protease inhibitors

8. What is Crystalluria? How can it be prevented?

9. Explain the life cycle of malarial parasite

10. Write short notes on polypeptide antibiotics.

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