Download Pharm D 3rd Year 2011 October 383817 Medicinal Chemistry Question Paper

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[KZ 817] OCTOBER 2011 Sub. Code: 3817

DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION

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THIRD YEAR

PAPER V - MEDICINAL CHEMISTRY

O.P. Code: 383817

Time: Three Hours Maximum: 100 marks

Answer ALL questions in the same order

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I. Elaborate on : Pages Time Marks

(Max.) (Max.) (Max.)

1. a) Describe various electronic parameters involved in QSAR study? 17 40 min. 20

   b) Explain the chemistry and mechanism of action of Cardiac glycosides.

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2. a) Explain the mechanism of action of various classes of Antiarrythmic agents. 17 40 min. 20

   b) Write the mechanism of action, SAR of sulphonyl ureas and the synthesis of any one.

II. Write notes on :

1. Write the SAR of Angiotensin —II antagonist. 4 10min. 6

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2. Write the structure, uses, mechanism of action and side effects of oxytetracycline. 4 10min. 6
3. Classify Antitubercular agents and write the synthesis of any one of them. 4 10min. 6
4. Write a note on Antiscabies and Antipedicular agents. 4 10min. 6
5. Classify Antiviral agents and write the structure of any three of them. 4 10min. 6
6. Enumerate the synthesis and mechanism of action of any one Anthelmentic agent. 4 10min. 6

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7. Explain the chemistry of estrogens. 4 10min. 6
8. Write a note on Antithyroid agents. 4 10min. 6
9. Write the synthesis, mechanism of action and side effects of mercaptopurine. 4 10min. 6
10. Classify antimalarials and write the synthesis of chloroquine. 4 10min. 6

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