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[KZ 817] OCTOBER 2011 Sub. Code: 3817
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER V ? MEDICINAL CHEMISTRY
Q.P. Code: 383817
Time: Three Hours
Maximum: 100 marks
Answer ALL questions in the same orde
I. Elaborate on :
Pages Time Marks
(Max.) (Max.) (Max.)
1. a) Describe various electronic parameters involved in
QSAR study?
17 40 min. 20
b) Explain the chemistry and mechanism of action of Cardiac
glycosides.
2. a) Explain the mechanism of action of various classes of
Antiarrythmic agents.
17 40 min. 20
b) Write the mechanism of action, SAR of sulphonyl ureas and
the synthesis of any one.
II. Write notes on :
1. Write the SAR of Angiotensin ?II antagonist.
4 10 min. 6
2. Write the structure, uses, mechanism of action and side
effects of oxytetracycline.
4 10 min. 6
3. Classify Antitubercular agents and write the synthesis of
any one of them.
4 10 min. 6
4. Write a note on Antiscabies and Antipedicular agents.
4 10 min. 6
5. Classify Antiviral agents and write the structure of any
three of them.
4 10 min. 6
6. Enumerate the synthesis and mechanism of action of any
one Anthelmentic agent.
4 10 min. 6
7. Explain the chemistry of estrogens.
4 10 min. 6
8. Write a note on Antithyroid agents.
4 10 min. 6
9. Write the synthesis, mechanism of action and side effects
of mercaptopurine.
4 10 min. 6
10. Classify antimalarials and write the synthesis of chloroquine.
4 10 min. 6
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