RAN-2006000102030001
IInd M.B.B.S. Examination
February - 2021
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Pharmacology: Paper - 1 Set-I
Pharmacology IInd MBBS
Time: 2 Hours ] <a href="https://www.firstranker.com/">FirstRanker.com</a>
RAN-2006000102030001 ] &p>
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Section I
Q-1. Answer the following: [1*10=10]
- Define 'Pharmacovigilance' and mention one reason why it should be must.
- Why is ipratropium bromide preferred over atropine for COPD (chronic obstructive pulmonary disease)?
- Name two conditions in which combination of neostigmine and atropine is given?
- Why nedocromil sodium should not be used for treatment of acute attack of asthma?
- Why frequency of administration of antacid administration is more in comparison for required effect?
- Write the drug of choice, its route and time of administration in motion sickness in long journey.
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RAN-2006000102030001 ] [1] [P.T.O.]
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g. Explain why propranolol should be avoided in Prinzmetal angina?
h. Give rationale for starting heparin and warfarin together in acute thromboembolic state.
i. Justify rationale of using Fixed Dose Combination (FDC) Hydrochlorothiazide with spironolactone.
j. What is the mechanism of action of clonidine in Hypertension?
Q-2. Answer any four of the following. [2*4=8]
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- What is the effect of changing urinary pH on drug excretion? Give one example for each for increase and decrease in pH.
- Enumerate prostaglandin analogues and their therapeutic uses.
- Mention various routes of administration of adrenaline with its therapeutic indication.
- Enumerate inotropic drugs. Explain the mechanism of action of Digoxin and mention its side effects.
- Describe role of inhalational corticosteroids in bronchial asthma and explain why in status asthmaticus bronchodilator is more effective by I/V route rather than inhalational route?
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Section II
Q-3. Answer any four of the following. [3*4=12]
- What is loading dose and maintenance dose? Explain with appropriate drug example.
- Enumerate alfa blockers. Mention uses and adverse effects of Phentolamine.
- Explain the concept of bioavailability. Describe various factors affecting bioavailability.
- Explain the role of ACE inhibitors in pharmacotherapy of congestive heart failure. What is the status of digitalis in CHF?
- Describe in detail different stages of dehydration due to diarrhea. Describe treatment of moderate and severe dehydration.
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Q-4. Answer any two of the following. [5*2=10]
- Enumerate various iron preparations. Describe important features of handling of iron by body after ingestion. Highlight the importance of these features in relation to therapy of iron deficiency anemia.
- Classify cholinomimetic agents. Write in detail about their therapeutic uses giving pharmacological basis of each use and their adverse effects.
- Enumerate various drugs from different categories for angina Describe the mechanism of action, limitations, and adverse effects of nitrates for classical angina
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RAN-2006000102030001 ] [2] [520]
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