Download VNSGU (Veer Narmad South Gujarat University or South Gujarat University) MBBS ?(Bachelor of Medicine, Bachelor of Surgery) 1st Year 2021 January Biochemistry Paper II Previous Question Paper
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First MBBS (New) Examination
January - 2021
Biochemistry - Paper-2
(New CBME Pattern)
k|Q"p : / Instructions
(1)
"uQ? v$ip?h?g r"ip"uhpmu rhNsp? D?fhlu `f Ah?e gMhu.
Seat No.:
Fill up strictly the details of signs on your answer book
Name of the Examination:
First MBBS (New)
Name of the Subject :
Biochemistry -Paper-2 (New CBME Pattern)
Subject Code No.: 2006000101030002
Student's Signature
Section A: MCQ (Separate paper attached)
(20 marks)
Instructions:
1. All questions are compulsory
2. Each MCQ has only one correct answer
3. One mark for correct answer. No negative marking
4. If more than one answer is ticked, it will be treated as wrong answer
5. Any tempering with answer will be treated as wrong answer
6. Use only ball point black pen. Pencil is strictly prohibited
7. Correct answer must be marked on OMR sheet with black pen & submit in
first30minutes
1
A nucleoside can be composed of all of the following, EXCEPT
a) Purine base
b)
Pentose sugar
c) Phosphate group
d)
Pyrimidine base
2
The two strands of DNA double helix are held together by:
a) Ionic bond
b)
Hydrogen bond
c) Nonpolar covalent bond
d)
Polar covalent bond
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3
Which of the following amino acid is exclusively ketogenic?
a) Leucine
b) Phenylalanine
c) Threonine
d) Isoleucine
4
Transaminase enzymes belongs to the class:
a)
Hydrolases
b)
Transferases
c) Oxidoreductases
d) Isomerases
5
Enzymes belongs to which group of biomolecules?
a) Carbohydrates
b) Proteins
c) Lipids
d) Phospholipids
6
Hemoglobin is a:
a) Monomeric protein
b)
Trimeric protein
c) Tetrameric protein
d)
Dimeric protein
7
In Maple syrup urine disease, which of the following compound is
accumulated?
a) Homogentisate
b) Methylmalonyl-CoA
c) Branched chain alpha keto acid
d) Homocysteine
8
Cysteine is synthesized from methionine and
a) Serince
b) Homoserine
c) Homocysteine
c) Threonine
9
Beriberiiscausedbyadeficiencyof:
a) Thiamine
b) Thymine
c) Threonine
d) Tyrosine
10
Increasedprothrombinetimeisobservedinthedeficiencyof
a) Vitamin K
b)
Vitamin D
c)
Vitamin A
d]
Vitamin K
11
Plasma albumin performs the following function, EXCEPT:
a) Maintenance of osmotic pressure
b) Transport
c) Solubilization of glucose
d) Nutritive
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12
Which of the following protein(s) is/are acute phase protein(s)?
a) C-Reactive protein
b)
Fibrinogen
c) Haptoglobin
d)
All of the above
13
Formation of okazaki fragments occur in the process of:
a) Transcription
b) Translation
c) Replication
d)
Reverse transcription
14
Reverse transcriptase catalyses:
a) Synthesis of RNA from DNA
b) Breakdown of RNA
c) Synthesis of DNA from RNA
d) Breakdown of DNA
15
The site to which RNA polymerase binds of the DNA template prior to the
initiation of transcription
a) Intron/exon junction
b)
Promoter
c) Terminator
d)
Initiator methionine code
16
Which of the following causes frame shift mutation?
a) Transition
b) Transversion
c)
Deletion
d)
Substitution of purine to pyrimidine
17
Anticodons are present on:
a) Coding strand of DNA
b)
mRNA
c) tRNA
d) tRNA
18
An operon is best described by:
a) A constitutively expressed gene system
b) An unregulated gene system
c) A coordinately regulated gene system
d) A gene that produces a monocistronic mRNA
19
AparticularRNAinamixturecanbeidentifiedby:
a) Western blotting
b)
Eastern blotting
c) Northern blotting
d)
Southern blotting
20
Whichofthefollowingchromatographictechniquesisbasedonmolecular
size?
a) Gelfiltrationchromatography
b) Ion exchange chromatography
c) Paper chromatography
d) Affinitychromatography
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Instructions for section B & C:
1. Use blue/black ball point pen only.
2. The numbers to the right indicates full marks.
3. Draw diagrams wherever necessary
Section B:
Q 2:
Long Answer Questions (ANY TWO OUT OF THREE)
(2 ? 10 = 20)
a) Describe the Absorption, transport, food sources, RDA, biochemical
functions,therapeuticuseanddeficiencymanifestationsofvitaminA.
b) Describe transcription mechanism in prokaryotes and add a note on
difference between prokaryotic and eukaryotic transcription.
c) Describe in detail about different types of enzyme inhibitions with suitable
examples.
Q 3:
Brief Answer Questions (ANY TEN OUT OF ELEVEN)
(10 ? 2 = 20)
a) Ubiquitin
b) Differences between eukaryotic and prokaryotic ribosomes
c) Deficiencymanifestationsoffolicacid
d) Denaturation of protein
e) Pellagra like sign and symptoms are seen in Hartnup disease.
f) Detoxificationofammonia
g) Structure of t-RNA
h) Persons with sickle cell trait are resistant to malaria caused by Plasmodium
falciparum.
i) Applications of recombinant DNA technology
j) Oncogens and Oncogenes are different - Explain
k) Biochemical basis of Alkaptonuria
Section
C:
(40
Marks)
Q 4:
Short answer questions (ANY FOUR OUT OF FIVE)
(4 ? 5 = 20)
a) Mutation
b) Posttranslationalmodifications
c) Principle and applications of chromatography
d) Gout
e) Catabolism of heme
Q 5:
Clinical Cases (ALL COMPULSORY)
(2 ? 10 = 20)
Case 1
A 7 year old male child was brought to the dental OPD with spongy,
swollen gums which bled on touch. He was also suffering from pain
and swelling in right knee. His diet contain mainly milk & Rice. No
vegetables or Fruits were given to him. On investigation, the child was
found to be anemic, it was microcytic hypochromic anemia.
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1. Deficiencyofwhichsubstancewillproducethesesymptoms?
Name the condition
2. Explain the reason for bleeding gums and painful swollen joint
3. What is the cause of anemia in this case?
4. What are the dietary sources of vitamin C?
5. If excessive doses of vit C are given, can it produce toxic effects?
What is the recommended daily allowance of vitamin C?
Case 2
52 years old patient was admitted to the casualty department of hospital
in a serious condition. He had become increasingly depressed after the
death of his wife. His daughter found him in an unconscious state when
she had come to see him in the morning. One and a half empty bottles
of alcohol were found in the room. When the alcohol was examined
for its contents it was found to be containing high amount of methanol.
Doctors on duty diagnosed that it was a case of methanol intoxication
and decided to start the intravenous infusion of ethanol
1. Which class of enzymes is required to metabolize alcohols?
2. Namethespecificenzymewhichactsonmethanol
3. Why methanol is toxic?
4. Ethanol infusion is based on the principle of competitive inhibition.
What is competitive inhibition?
5. In competitive inhibition K is increased but V is not affected.
m
max
Explain
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This post was last modified on 28 December 2021