Download B.Pharm 1st Year 2017 August 564252 Pharmaceutical Organic Chemistry Question Paper

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B.PHARM. DEGREE EXAMINATION

FIRST YEAR

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PAPER II - PHARMACEUTICAL ORGANIC CHEMISTRY

Time: Three hours Maximum: 100 Marks

I. Elaborate on: (2x20=40)

1. a) Write two methods of preparation and synthetic utility of Diazonium salts. b) Describe the generation, stability and applications of 1) Carbanions 11) Carbenes 111) Free radicals.
2. a) Write the preparation and properties of (i) Diphenyl methane (i) Anthracene. b) Give the preparation and medicinal uses of (i) Dicophane (ii) Amphetamine.

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II. Write notes on: (8x5=40)

1. Describe the methods of preparation and reactions of alkynes.
2. Describe about Cannizaro and crossed Cannizaro reaction.
3. Write the mechanism of reactions of benzene with examples.
4. Give the preparation and medicinal uses of Gammaxene.

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5. Write the preparation, tests for purity and medicinal uses of Benzoic acid.
6. Describe in detail about electrophiles and nucleophiles.
7. Write the preparation of carboxylic acids.
8. Write short notes on Coulson and Moffitt’s modification.

III. Short answers on: (10x2=20)

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1. Define resonance effect.
2. What is dipole moment?
3. Any one preparation of Glycol.
4. Two reactions of Cycloalkanes.
5. What is Huckel’s rule?

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6. Give the structure and medicinal use of Carbromal.
7. Give the structural formula and IUPAC name of butyl methyl ketone.
8. What is Hinsberg reaction?
9. What are epoxides?
10. What is Saytzeff’s rule?

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