Download B.Pharm 1st Year 2011 February 564252 Pharmaceutical Organic Chemistry Question Paper

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February 2011

[KY 758] Sub. Code : 4252

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FIRST B. PHARM. DEGREE EXAMINATION.

(Regulations 2009) Candidates Admitted from 2009-2010

Paper I — PHARMACEUTICAL ORGANIC CHEMISTRY

Q.P. Code : 564252

Time : Three hours Maximum : 80 marks

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I. Essay questions: Answer any TWO questions. (2x20=40)

1. (a) Define aromatic electrophilic substitution reactions. Discuss the reaction and mechanism of nitration, sulphonation, and friedel-craft reaction. (15)
   (b) Describe clemmensen reduction with a suitable example (5)
2. (a) Define elimination reaction. Discuss the mechanism of E1 and E2 reaction with a suitable example. (10)
   (b) Write any four general methods of preparation of alkyl halides. (10)

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3. (a) Discuss Bayer’s strain theory with suitable examples. (10)
   (b) Explain the facts supporting Kekule structure of Benzene. (10)

II. Write short notes: Answer any SIX questions. (6x5=30)

1. Write a short note on the peroxide effect.
2. Explain nucleophilic substitution reaction with an example.

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3. Write the preparation and synthetic utility of diazonium salts.
4. Outline the general methods of preparation of alkynes.
5. Discuss the basicity of amines.
6. Write a note on the Inductive effect.
7. Write a note on free radical reaction.

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8. Write any two methods of preparation of alcohol.

III. Short answers: Answer any FIVE questions (5x2=10)

1. Tollens reagent.
2. Define hyper-conjugation.
3. Explain conjugated dienes.

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4. Explain resonance effect.
5. Lucas test.
6. Give the structure for 5-Bromo-4-methyl-hex-3-en-2-one.
7. Give the IUPAC name for HO -CH₂ -CH₂ - COOH.

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