Download B.Pharm 3rd Year 2012 February 564262 Medicinal Chemistry I Question Paper

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February 2012

[LA 4262] Sub. Code: 4262

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THIRD B.PHARM. EXAMINATION

Paper I - MEDICINAL CHEMISTRY -1

Q.P. Code: 564262

Time : Three hours Maximum: 100 Marks

Answer ALL questions.

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1. I. Elaborate on: (2 x 20 = 40)

   1. (a) Define Diuretics? Classify with example.(2+6)

      (b) Give the Structural Activity Relationship for the mercurial diuretics.(7)

      (c) Derive the synthesis for (1) Acetazolamide (it) Furosemide.(5)

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   2. (a). Define and Classify local anaesthetics with example. (2+3)

      (b). Synthesis the followings: (i) Procaine (ii) Lignocaine (iii) Benzocaine (iv) Dibucaine. (10)

      (c) Give the Structural Activity Relationship of local anaesthetics.(5)

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2. II. Write notes on: (8 x 5 = 40)

   1. Write a note on Biolsosterism.
   2. Add brief note on Phase II Bio transformation pathway.
   3. Give the Synthesis for (a) Phentoin (b) Ibuprofen.
   4. Write a note on cholinergic receptors.

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   5. Biosynthesis of Eicosanoids.
   6. Define Sedative and hypnotics? Classify with example.
   7. Add a note on Proton Pump Inhibitors.
   8. Give the synthesis for the following: (i) Salbutamol (ii) Promethazine.

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3. III. Short Answers: (10 x 2 = 20)

   1. Give the Structure and Medicinal uses for the following:
   1. Aspirin.
   2. Indomethicin.
   3. Chlorpromazine HCI.

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   4. Diazepam.
   5. Impiramine. HCL
   2. Define the following Terms:
   1. Chelation.
   2. Carbonic Anhydrase Inhibitors.

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   3. Prodrug.
   4. Tranquillise
   5. Antiepileptics.

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