Download B.Pharm 3rd Year 2013 August 564262 Medicinal Chemistry I Question Paper

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THIRD YEAR B.PHARM. EXAM

PAPER II - MEDICINAL CHEMISTRY -I

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Q.P. Code: 564262

Time: Three Hours Maximum: 100 marks

1. I. Elaborate on: (2X20=40)
   1. a) Explain the various types of Phase — I Biotransformation Pathways.
   2. b) Discuss factors affecting metabolism.

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2. 1. a) Classify H1 Receptor Antagonists? Give the synthesis for the following drugs.
      1. 1) Diphenhydramine hydrochloride
      2. ii) Triprolidine hydrochloride
      3. iii) Cyclizine hydrochloride
      4. iv) Promethazine hydrochloride.

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   2. b) Brief the SAR of H1 — receptor antagonist.
3. II. Write notes on: (8X5=40)
   1. Explain the chemistry and biological significance of prostaglandins.
   2. Outline the synthetic steps involved in a) Lignocaine b) Procaine.
   3. Classify Anti-inflammatory agents and write the synthesis of Ibuprofen.

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   4. Brief the SAR of barbiturates.
   5. Describe the synthesis and clinical use of the following: (a) Dextroamphetamine (b) Nikethamide.
   6. Name the cholinergic blocking agents and explain the synthesis of any one of them.
   7. How does hydrogen bonding affect biological activity? Explain with example.
   8. Explain the methods of development of prodrugs.

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4. III. Short Answers on: (10X2=20)
   1. Chelation with examples.
   2. Define antitussive and Write the structure of any two drugs?
   3. Mechanism of action of Acetazolamide.
   4. Structure, Chemical name and Uses of Phenobarbitone.

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   5. Neuromuscular blocking drugs.
   6. Synthesis of Propranolol.
   7. Write the structure of any two CNS stimulants.
   8. Describe the synthesis and clinical use of thiamylal sodium.
   9. Dicuss the SAR of phenothiazines.

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   10. Proton pump inhibitors

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