Download B.Pharm 3rd Year 2013 August 564262 Medicinal Chemistry I Question Paper

Download B.Pharmacy (Bachelor of Pharmacy) 3rd Year (Third Year) 2013 August 564262 Medicinal Chemistry I Previous Question Paper

(LD 4262)





AUGUST 2013



Sub. Code: 4262

THIRD YEAR B.PHARM. EXAM

PAPER II ? MEDICINAL CHEMISTRY -I

Q.P. Code: 564262

Time: Three Hours







Maximum: 100 marks



I. Elaborate on:

(2X20=40)





1. a) Explain the various types of Phase ? I Biotransformation Pathways.

b) Discuss factors affecting metabolism.

2. a) Classify H1 Receptor Antagonists? Give the synthesis for the following
drugs.




i) Diphenhydramine hydrochloride ii) Triprolidine hydrochloride





iii) Cyclizine hydrochloride iv) Promethazine hydrochloride.

b) Brief the SAR of H1 ? receptor antagonist.

II. Write notes on:

(8X5=40)



1. Explain the chemistry and biological significance of prostaglandins.
2. Outline the synthetic steps involved in a) Lignocaine b) Procaine.
3. Classify Anti-inflammatory agents and write the synthesis of Ibuprofen.
4. Brief the SAR of barbiturates.
5. Describe the synthesis and clinical use of the following:

(a) Dextroamphetamine (b) Nikethamide.

6. Name the cholinergic blocking agents and explain the synthesis of any one

of them.

7. How does hydrogen bonding affect biological activity? Explain with

example.

8. Explain the methods of development of prodrugs.





III. Short Answers on:

(10X2=20)



1. Chelation with examples.
2. Define antitussive and Write the structure of any two drugs?
3. Mechanism of action of Acetazolamide.
4. Structure, Chemical name and Uses of Phenobarbitone.
5. Neuromuscular blocking drugs.
6. Synthesis of Propranolol.
7. Write the structure of any two CNS stimulants.
8. Describe the synthesis and clinical use of thiamylal sodium.
9. Dicuss the SAR of phenothiazines.
10. Proton pump inhibitors


*******