Download B.Pharm 3rd Year 2014 August 564262 Medicinal Chemistry I Question Paper

FirstRanker.com

Third Year B.Pharm. Exam

Paper II - Medicinal Chemistry - I

--- Content provided by FirstRanker.com ---

Time: Three hours Maximum: 100 marks

1. Essay: (2X20=40)
   1. Discuss the basic concept and application of Prodrug design.
   2. Write a brief note on phase —II biotransformation pathway.
2. 1. What are sedative and Hypnotics? Classify with examples.

   --- Content provided by​ FirstRanker.com ---

   2. Explain the synthesis for the following:
      1. Barbital
      2. Diazepam
      3. Chloropromazine hydrochloride
      4. Valproic acid

   --- Content provided by⁠ FirstRanker.com ---

   3. Discuss the structure activity relationship of Barbiturates.

1. Short notes: (8X5=40)

1. Write the structure and clinical uses of a) Indomethacin b) Ibuprofen c) Haloperidol d) Cyclizine hydrochloride.
2. Outline the synthetic steps involved in a) Meperidine b) Methadone

--- Content provided by⁠ FirstRanker.com ---

3. Classify Diuretics and write the synthesis and SAR of Chlorthiazide.
4. Discuss about types of receptors.
5. Describe the synthesis and clinical use of the following: a) Imipramine hydrochloride b) Dextroamphetamine sulphate.
6. Name the cholinergic agents and explain the synthesis of any one of them.
7. How does chelation affect biological activity? Explain with example.

--- Content provided by‍ FirstRanker.com ---

8. Classify adrenergic blocking agents. Outline the synthesis of metoprolol.

1. Short Answers: (10X2=20)

1. Hydrogen bonding with examples.
2. Define general anaesthetics and write the structure of any two drugs.
3. Mechanism of action of procaine.

--- Content provided by⁠ FirstRanker.com ---

4. Structure, Chemical Name and uses of Diphenhydramine.
5. Prostaglandins.
6. Give synthesis and uses of Phenylephrine.
7. Write the structure of any two cholinergic blocking agents.
8. Protein Binding.

--- Content provided by‌ FirstRanker.com ---

9. Discuss the SAR of Tricyclic antidepressants.
10. H1 receptor antagonists.

FirstRanker.com