Download B.Pharm 3rd Year 2015 February 564262 Medicinal Chemistry I Question Paper

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THIRD YEAR B.PHARM. EXAMINATION

PAPER II - MEDICINAL CHEMISTRY -1

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Time: Three hours Maximum: 100 marks

1. Essay: (2 x 20 = 40)

   1. Define and classify CNS stimulants with suitable examples.
   2. Explain the mechanism, structure activity relationship and synthesis of
      1. Imipramine
      2. Amitriptyline

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   3. Write the synthesis of metoprolol and chlorcyclizine
2. 1. Define and classify analgesics and anti-inflammatory agents. Write the synthesis and Mechanism of action of Ibuprofen.
   2. Outline the structure, physiochemical properties and biosynthesis of adrenergic Neurotransmitters.

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II. Short notes: (8 x 5 = 40)

1. Classify antipsychotics and write a note on SAR of chlorpromazine.
2. Describe about surface activity in relation to biological action.
3. Outline the stereochemistry of cholinergics with examples

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4. Write the synthesis of
   1. Furosemide
   2. Naloxone
5. Explain about optical isomerism influencing biological action.
6. Distinguish between the structure and structure activity relationship of omeprazole and lansoprazole.

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7. Explain the mechanism of action and use of
   1. Ketamine
   2. Dextroamphetamine
   3. Amiloride
   4. Loratidine
   5. Acetaminophen

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8. Define and classify anxiolytics. Write the synthesis of barbital.

III. Short answers: (10 x 2 = 20)

1. Define the following terms with examples:
   1. Tranquilizer
   2. Parasympatholytics

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2. Write the structure and use of
   1. Cimetidine
   2. Isoproterenol
3. Explain the structure activity relationship of Noscapine

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4. Types of receptor
5. Significance of drug metabolism
6. Structure and uses of Salbutamol
7. Adrenergic receptor hypothesis
8. Write the structure and mode of action of
   1. Piperocaine

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   2. Tetracaine
9. Redox potential
10. Write the structure of
    1. Salsalate
    2. Oxymorphine

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