Download B.Pharm 3rd Year 2017 August 564262 Medicinal Chemistry I Question Paper

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B.PHARM. DEGREE EXAMINATION

THIRD YEAR

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PAPER II - MEDICINAL CHEMISTRY - I

Time: Three hours Maximum: 100 Marks

I. Elaborate on: (2x20=40)

1. a) Define Receptor and discuss the theories involved in Drug Receptor complex.
   b) Explain the different types of reaction in phase I metabolic pathways.

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2. a) Discuss the classification, mode of action and SAR of NSAIDs.
   b) Give the synthesis for Indomethacin, Ibuprofen and Phenylbutazone.

II. Write notes on: (8x5=40)

1. Write about applications of prodrug design.
2. Classify sedative and hypnotics with examples and give the synthesis of diazepam.

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3. Write a note on: i) Isosterism ii) Hydrogen bonding.
4. Define CNS stimulants and give the synthesis for: i) Nikethamide ii) Imipramine HCL.
5. Discuss Sympathomimetic agents and give the synthesis of salbutamol.
6. Explain in detail about antihistaminic agents.
7. Discuss SAR of barbiturates.

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8. Define and classify diuretics with suitable examples.

III. Short answers on: (10x2=20)

1. Define the term Tranquilliser.
2. Structure and uses of methohexital sodium.
3. Synthesis of Mephenytoin.

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4. Write the structures of Homatropine HBr and Tropicamide.
5. Note on Neuromuscular blockers.
6. Define Anti-tussive agents.
7. Mode of action of Halothane.
8. Structure and use of Naproxen.

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9. Note on Prostaglandins.
10. H₁ receptor antagonists.

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