B.Pharm 3rd Year Last 12 Years 2010-2022 Previous Question Papers (Bachelor of Pharmacy)
(AUGUST 2020 EXAM SESSION)
B. PHARMACY DEGREE EXAMINATION
THIRD YEAR - (Regulation from 2009-2010)
PAPER II - MEDICINAL CHEMISTRY -1
Time: Three hours Answer ALL questions Maximum: 100 Marks
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[LR 1220] DECEMBER 2020 Sub. Code: 4262(AUGUST 2020 EXAM SESSION)
B. PHARMACY DEGREE EXAMINATION
THIRD YEAR - (Regulation from 2009-2010)
PAPER II - MEDICINAL CHEMISTRY -1
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O.P. Code: 564262Time: Three hours Answer ALL questions Maximum: 100 Marks
I. Elaborate on: (2x20=40)
- Explain the following physiochemical parameters related to biological activity with Example (4x5=20)
a) Steric effect b) Protein binding ¢) Geometrical isomerism d) Hydrogen bonding. - a) Define anticonvulsants? Classify with examples.(6)
b) Give detailed account of Structure Activity Relationship of Local anesthetics. (6)
¢) Outline the synthesis for (i) Chlorpromazine HCI (ii) Thiamylal sodium.(4+4)
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II. Write notes on: (8x5=40)
- Describe the biosynthesis of adrenergic neurotransmitters.
- Relate the structural features of any four drugs from cholinergic.
- Give four structures of quaternary ammonium compounds as Ganglionic blockers.
- Outline the synthesis and uses of Indomethacin.
- Give the route of synthesis of Chlorthiazide and Procaine.
- Draw any four structures of antihistamines under amino alkyl ethers.
- Give the synthesis and mechanism of action of Doxepin HCl.
- Classify Sedatives and Hypnotics with at-least one structure for each class.
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III. Short answers on: (10x2=20)
- Draw the structure and medicinal uses of Methadone HCl.
- Summarize at-least three points about chemistry of Eicosanoids.
- Sketch the structure and medicinal uses of Codeine and Morphine.
- Write a note on Ranitidine and Famotidine in terms of chemistry.
- Outline the structures of Halothane and Enflurane.
- Give two examples as Prodrugs.
- Draw the structure and uses of Propantheline.
- Give two examples of potassium sparing diuretics.
- Sketch two structures of bronchodilators.
- Give two reactions of Phase-I Metabolism.
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