Download B.Pharm 4th Year 2016 August 564270 Modern Methods of Pharmaceutical Analysis Question Paper

(LJ 4270)

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AUGUST 2016

Sub. Code: 4270

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FOURTH YEAR B.PHARM. EXAMINATION

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PAPER IV ? MODERN METHODS OF PHARMACEUTICAL

ANALYSIS

Q.P. Code: 564270

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Time: Three hours

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Maximum: 100 Marks

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I. Essay:

(2 x 20 = 40)

1. With a neat diagram, explain the principle, different vibrational modes of

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molecules, instrumentation and applications of Infrared spectrophotomete


2. a) Explain the principle and instrumentation of flame emission spectroscopy.

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b) Describe the principle and different types of conductometric titrations with
examples.

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II. Short notes:

(8 x 5 = 40)

1. Explain the various factors that affect the fluorescent intensity.

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2. Describe the working principle and instrumentation of nephelomete
3. Explain the different type of electronic transitions involved in UV spectroscopy

with examples.

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4. Describe the construction and working of dropping mercury electrode with a

diagram.

5. Describe briefly the various parameters involved in the calibration and validation

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of analytical instruments.

6. Explain the principle, different type of ion exchange resins and mechanism

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involved in ion exchange chromatography.

7. Explain the principle and applications of X-ray diffraction technique.
8. Explain the various methods of detection of compounds in thin layer

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chromatography.


III. Short answers:

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(10 x 2 = 20)

1. Define chromophore and hypsochromic shift.
2. Define retention time and retention volume.
3. What is ultracentrifugation?

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4. List at least four different type ions produced in mass spectra.
5. What is HETP? How it is related to number of theoretical plates and length of the

column?

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6. Mention two examples each of reference and indicator electrode.
7. Define finger print region.
8. Write any two differences between NMR and ES
9. Define tailing facto
10. Write any two limitations of GLC.

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