Download B.Pharm 4th Year 2017 August 564270 Modern Methods of Pharmaceutical Analysis Question Paper

(LL 4270)

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AUGUST 2017 Sub. Code: 4270



B.PHARM. DEGREE EXAMINATION

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FOURTH YEAR

PAPER IV ? MODERN METHODS OF PHARMACEUTICAL

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ANALYSIS

Q.P. Code: 564270

Time: Three hours

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Maximum: 100 Marks

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I. Elaborate on:

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(2 x 20 = 40)



1. a) Explain the principle of NM What ar e the conditions for nuclei to exhibit

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nuclear magnetic resonance?
b) Explain the terms chemically equivalent protons, shielding and deshielding,
splitting of signals.

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2. a) Explain the components of a Gas-Liquid Chromatography assembly and

explain its working.
b) What are the different types of columns used in GLC? Explain.

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II. Write notes on:

(8 x 5 = 40)

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1. Describe the components of a Nephelomete
2. What are the factors that affect fluorescence?

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3. Describe the construction and working of a hollow cathode lamp.
4. Explain the construction and working of the standard calomel electrode.
5. Explain the principle of counter current extraction.
6. Explain `Dead Stop End Point Titrations'.
7. Outline the basic concept of Total Quality Management.

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8. Discuss how we may arrive at a formula to determine the number of vibrational

degrees of freedom for a linear molecule and a non linear molecule.

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III. Short answers on:

(10 x 2 = 20)

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1. Name two solvents frequently used in Reverse phase HPLC.
2. Differentiate between Isocratic system and gradient elution system.
3. What are the conditions for the absorption of Infra-Red radiation?
4. What is molecular ion peak?

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5. What is a Guard Column used in HPLC?
6. What is Gel filtration?
7. What is equivalent conductance?
8. What is half wave potential on a polarogram?
9. Give two applications of Turbidometric assays.

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10. What is X-ray diffraction?



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