Download B.Pharm 4th Year 2020 December 564270 Modern Methods of Pharmaceutical Analysis Question Paper

--- Content provided by FirstRanker.com ---

(LR 4270)

--- Content provided by FirstRanker.com ---

DECEMBER 2020 Sub. Code: 4270

(AUGUST 2020 SESSION)

--- Content provided by FirstRanker.com ---

B.PHARM. DEGREE EXAMINATION

FOURTH YEAR

PAPER IV ? MODERN METHODS OF PHARMACEUTICAL

--- Content provided by FirstRanker.com ---

ANALYSIS

Q.P. Code: 564270

--- Content provided by FirstRanker.com ---

Time: Three hours

--- Content provided by FirstRanker.com ---

--- Content provided by FirstRanker.com ---

Maximum: 100 Marks



I. Elaborate on:

--- Content provided by FirstRanker.com ---

(2 x 20 = 40)

1. a) What is Ion exchange chromatography.

--- Content provided by FirstRanker.com ---

b) What are the different types of exchangers?
c) Explain in detail the mechanism of Ion exchange.


2. a) Explain the principle and instrumentation of Fuorimetry.

--- Content provided by FirstRanker.com ---

b) What are the factors that influence Fluorescence? Explain with examples.


II. Write notes on:

--- Content provided by FirstRanker.com ---

(8 x 5 = 40)

1. In polarography what is half wave potential? explain.
2. Draw the proton NMR spectrum of 1,3 ? dibromopropane showing the number of

--- Content provided by FirstRanker.com ---

signals, their relative positions and splitting of signals.

3. Describe a typical IR spectrum. Include information about vertical and horizontal

--- Content provided by FirstRanker.com ---

axes and the broad regions. Where would you expect the absorption to occur for
benzene?

4. What are the methods of detection in thin layer chromatography?
5. Describe the construction and working of a calomel electrode.

--- Content provided by FirstRanker.com ---

6. Enumerate the different methods of ionization in mass spectrometry. Explain any

one metho

7. Explain the basic concepts of good laboratory practices?

--- Content provided by FirstRanker.com ---

8. Briefly explain the calibration of UV Spectrophotomete

III. Short answers on:

(10 x 2 = 20)

--- Content provided by FirstRanker.com ---

1. Give two methods of preparation of a sample for IR spectroscopy.
2. In Polarography, why is potassium chloride solution used as supporting

electrolyte?

--- Content provided by FirstRanker.com ---

3. What is the role of a salt Bridge?
4. Enumerate the principles of total quality.
5. What is Zeta Potential?
6. Draw the graph for a Conductometric titration of a weak acid with a strong base.

--- Content provided by FirstRanker.com ---

7. Distinguish between calibration and validation.
8. What are indicator electrodes? Give one example.
9. Distinguish between Accuracy and Precision.
10. What are the electrodes used in Polarography?

--- Content provided by FirstRanker.com ---

*******