Download Maharashtra University of Health Sciences (MUHS) MBBS (Bachelor of Medicine, Bachelor of Surgery) 1st Year Biochemistry Syllabus
(Based on Competency Table published by Medical Council of India.Students/Teachers are directed to refer competency table
published on MCI Website for details)
Subject: Biochemistry
Year: First MBBS
Competency No.
Topics & Subtopics
1
Basic Biochemistry
Molecular and functional organization of cell and its subcellular components
1.1
Describe the molecular and functional organization of a cell and
its subcellular components.
2
Enzymes
2.1
Biochemical nature of enzyme, isoenzyme, alloenzyme, coenzyme & co-factors
Explain fundamental concepts of enzyme, isoenzyme,
alloenzyme, coenzyme & co-factors. Enumerate the main
IUBMB enzyme classification
classes of IUBMB nomenclature.
Estimation of SGOT (AST)& SGPT (ALT) with its normal range and clinical significance.
2.2 Observe
the estimation of SGOT & SGPT
2.3
Mechanism of enzyme action, factors affecting enzyme activity, brief concept of enzyme
Describe and explain the basic principles of enzyme activity
kinetics with special reference to Vmax & km.
2.4
Enzyme inhibition. Various inhibitors as drugs and poisons
Competency No.
Topics & Subtopics
Describe and discuss enzyme inhibitors as poisons and drugs
and as therapeutic enzymes
Diagnostic and therapeutic importance of various serum enzymes in various disorders
2.5
Describe and discuss the clinical utility of various serum
enzymes as markers of pathological conditions.
Analytical uses of Enzymes in laboratory investigations (enzyme based assays)
2.6
Discuss use of enzymes in laboratory investigations
(Enzymebased assays)
Interpret various serum enzymes of liver & biliary tract, Pancreas, cardiac & skeletal muscle
2.7
in various disorders
Interpret laboratory results of enzyme activities & describe the
clinical utility of various enzymes as markers of pathological
conditions.
3
Chemistry & Metabolism of Carbohydrates
3.1
Discuss and differentiate monosaccharides, di-saccharides and
polysaccharides giving examples of main carbohydrates as
Classification of carbohydrates with examples and functions of monosaccharides giving
energy fuel, structural element and storage in the human body
examples as energy fuel, glycosides and its therapeutic importance, disaccharides with
examples and importance, polysaccharides with examples as storage form like
glycogen, structural elements like glycosaminoglycan's in the human body, resistant
starch, glycemic index, and dietary fiber. Clinical importance of dextran's
Digestion & absorption, transport and storage of carbohydrates, Lactose intolerance and
3.2
sucrase deficiency disorders
Describe the processes involved in digestion and assimilation of
carbohydrates and storage.
3.3
Competency No.
Topics & Subtopics
Describe and discuss the digestion and assimilation of
carbohydrates from food.
3.4
Define and differentiate the pathways of carbohydrate
metabolism(glycolysis, gluconeogenesis, glycogen metabolism,
Pathway, energetics, regulation & clinical diseases / disorders of - Glycolysis including
HMP shunt).
Rappaport Leubering cycle, Gluconeogenesis, Glycogenesis, Glycogenolysis , HMP
pathway , Uronic acid pathway, Galactose & Fructose metabolism
3.5
Describe and discuss the regulation, functions and integration
of carbohydrate along with associated diseases/disorders.
TCA cycle Pathway,energetics, regulation & its concepts as amphibolic pathway
3.6
Describe and discuss the concept of TCA cycle as a amphibolic
pathway and its regulation.
3.7 To be clubbed with 3.4 & 3.6
Common poisons that inhibit crucial enzymes of carbohydrate metabolism like:
Iodoacetate, fluoride & arsenite as poisons that inhibit enzymes of glycolysis
Describe the common poisons that inhibit crucial enzymes of
Fluoroacetate, arsenite & malonate as poisons that inhibit enzymes of TCA cycle
carbohydrate metabolism (eg: fluoride, arsenate)
Interpretation of the results of blood glucose, Glycated hemoglobin & GTT as per WHO
3.8 & 3.10
guidelines in Diabetes mellitus including gestational diabetes and other laboratory
3.8: Discuss and interpret laboratory results of analytes
investigation like urinary glucose, urinary ketone bodies.
associated with metabolism of carbohydrates.
(to be clubbed with comp no 11.17- Diabetes Mellitus)
Interpretation of the results of blood & urinary galactose levels in galactosemia.
3.10
Interpretation of blood G6PD levels
Interpret the results of blood glucose levels and other
Laboratory investigations related to disorders of carbohydrate
metabolism.
Competency No.
Topics & Subtopics
3.9
Regulation of blood glucose in fed and fasting state in normal health & changes in
Discuss the mechanism and significance of blood glucose
diabetes mellitus.
regulation in health and disease.
4
Chemistry & Metabolism of Lipids
4.1
Definition & classification of lipids including classification of fatty acids, their
Describe and discuss main classes of lipids
nomenclature, numbering, functions & biological importance of various lipids like fatty
(Essential/nonessential fatty acids, cholesterol and hormonal
acids, cholesterol , hormonal steroids, triglycerides, major phospholipids and
steroids, triglycerides, major phospholipids and sphingolipids)
sphingolipids
relevant to human system and their major functions.
4.2
Describe the processes involved in digestion and absorption of
Digestion, absorption and transport of lipids along with abnormalities like lipid
malabsorption.
dietary lipids and also the key features of their metabolism
Metabolism of fatty acids (-oxidation of even and odd carbon fatty acids), regulation,
energetics and disorders associated with oxidation of fatty acids, Formation & fate of
ketone bodies, its significance, regulation and associated disorders like ketosis.
In brief de novo fatty acid biosynthesis- site & organs, precursors, enzyme complex,
product formed & regulatory steps.
Biosynthesis of triacylglycerol and fate of triacylglycerol formed in liver & adipose tissue,
its significance and regulation, Metabolic role of adipose tissue and disorders of lipid
transport and storage like fatty liver.
In brief Cholesterol biosynthesis- site & organs, precursors, key enzymes, product formed
& regulatory step, metabolic fate & excretion
Competency No.
Topics & Subtopics
4.3
Metabolism of various lipoproteins and hyperlipoproteinemia's,
Explain the regulation of lipoprotein metabolism & associated
hypolipoproteinemiasabetalipoproteinemias & Tangiers disease.
disorders.
4.4
Classification structure and functions of lipoproteins- (To be clubbed with 4.1)
Describe the structure and functions of lipoproteins, their
functions, interrelations & relations with atherosclerosis
Metabolic interrelationship between various lipoproteins, Role of lipoproteins in
transport of cholesterol and reverse cholesterol transport, atherosclerosis- (To be
clubbed with 4.3)
4.5 & 4.7
Various lipid profile tests with their biological reference intervals. Interpret lipid profile
Interpret laboratory results of analytes associated with
results in various disorders like hyper/hypolipoproteinemias, diabetes mellitus, nephrotic
metabolism of lipids
syndrome, disorders of thyroid etc.
4.6
Various eicosanoid classes (prostaglandins, leukotrienes & thromboxanes), their
functions. Key features of synthesis of eicosanoids and inhibitors of eicosanoid synthesis,
Describe the therapeutic uses of prostaglandins and inhibitors
therapeutic uses of prostaglandins
of eicosanoid synthesis.
Same as 4.5
4.7
Interpret laboratory results of analytes associated with
metabolism of lipids.
5
Chemistry and Metabolism of Proteins
5.1
General nature of amino acid, classification and importance of amino acids with
Describe and discuss structural organization of proteins.
examples, peptide bond formation, biologically important peptides, different levels of
protein structure including disulfide & weak bonds with examples and clinical
significance.
Competency No.
Topics & Subtopics
5.2
Definition, various classifications with examples and functions of proteins, plasma
Describe and discuss functions of proteins and
proteins, structure - function relationship of proteins like myoglobin, normal & abnormal
structurefunction relationships in relevant areas e.g.
hemoglobin
hemoglobin and selected hemoglobinopathies
5.3
Digestion, absorption and transport of dietary proteins with related disorders like
Describe the digestion and absorption of dietary proteins.
Hartnup disease, cystinuria & glycinuria.
5.4
Describe common disorders associated with
Role of transamination & deamination reactions in metabolism of amino acids in the
protein metabolism.
formation of ammonia with their clinical significance.
Transport of ammonia, pathway of urea cycle, its significance, regulation and metabolic
disorders associated with urea cycle.
Metabolic pathways for Glycine, Phenylalanine & Tyrosine, Sulphur containing amino
acids (Methionine, Cysteine & Cystine) and branch chain amino acids (Valine, Isoleucine
& Leucine), their role in biosynthesis of variety of specialized biomolecules, associated
metabolic disorders
For Tryptophan- Only important biomolecules formed & clinical significance.
5.5
Interpret laboratory results of protein metabolism for example:
Interpret laboratory results of analytes associated with Levels of various metabolites in blood or urine in metabolic disorders like- urea cycle
metabolism of proteins.
disorders, Phenylketonuria, Tyrosinemia, Alkaptonuria, Hartnups disease, MSUD,
cystinuria & homocystinuria
6
Metabolism and Homeostasis
6.1
Integration of carbohydrate, protein and lipid metabolism at cellular and tissue or organ
Discuss the metabolic processes that take place in specific
level with its significance, Metabolic processes with role of specific organs in fed, fasting
organs in the body in the fed and fasting states.
and starvation states.
Competency No.
Topics & Subtopics
6.2
Important steps in de novo biosynthesis of purine and pyrimidine nucleotides and their
Describe and discuss the metabolic processes in which
regulation, enzymes of the nucleotide biosynthesis that are inhibited by anticancer drugs,
nucleotides are involved.
salvage pathway for the synthesis of purine nucleotides with its significance, catabolism
of purine and pyrimidine nucleotides.
Disorder of nucleotide metabolism like gout, Lesch-Nyhan syndrome, orotic aciduria, with
6.3
diagnostic tests & biochemical mechanism of nutritional & drug therapy.
Describe the common disorders associated with nucleotide
metabolism.
6.4
Lab results of analytes related with gout & Lesch-Nyhan syndrome. Levels of uric acid in
Discuss the laboratory results of analytes associated with gout & blood & urine and presence of urate crystals in synovial fluid in gout, levels of uric acid in
Lesch-Nyhan syndrome.
blood
Sources, biochemical functions, daily requirement and deficiency manifestations of fat
6.5
soluble vitamins (Vitamin A, D, E & K).
Describe the biochemical role of vitamins in the body and explain Sources, biochemical functions and deficiency manifestations of water soluble vitamins
the manifestations of their deficiency
(Thiamine, Riboflavin, Niacin, Pantothenic acid, Pyridoxine, Biotin, Folic acid, Cobalamin
and vitamin C)
6.6
Electron transport chain, mechanism of oxidative phosphorylation (chemiosmotic
Describe the biochemical processes involved in generation of
theory), substrate level phosphorylation, Uncouplers & Inhibitors of electron transport
energy in cells.
chain , shuttle systems for transport of extra-mitochondrial NADH
6.7
Acids, bases and buffers, mechanism of action of buffer, dietary sources of acids, bases,
normal pH of body fluids. Role of blood buffers, respiratory system & kidney in regulation
Describe the processes involved in maintenance of normal pH,
of blood pH.
water & electrolyte balance of body fluids and the
derangements associated with these.
Disorders associated with blood pH (acidosis and alkalosis) & their compensatory
mechanisms, anion gap & its clinical importance.
Competency No.
Topics & Subtopics
Total body water and its compartmental distribution, various electrolytes- sodium,
potassium and chloride, their distribution and clinical conditions related to their plasma
level alterations, maintenance of normal water and electrolyte balance and disorders
associated with water and electrolyte imbalance.
Interpretation of results of arterial blood gas (ABG) analysis in acidosis and alkalosis.
6.8
Discuss and interpret results of Arterial Blood Gas (ABG)
analysis in various disorders.
6.9
Dietary food sources, daily requirement, biochemical functions, metabolism and
homeostasis of: Calcium, phosphorus & magnesium, trace elements (copper, fluoride,
Describe the functions of various minerals in the body, their
iodine, iron, manganese, selenium & zinc)
metabolism and homeostasis.
6.10
Clinical conditions related to plasma level alterations of: Calcium, phosphorus &
Enumerate and describe the disorders associated with mineral
magnesium Trace elements (copper, fluoride, iodine, iron, manganese, selenium & zinc)
metabolism.
6.11
Structure and functions of hemoglobin, role of 2,3-bisphosphoglycerate (BPG) in oxygen
Describe the functions of heme in the body and describe the
binding and delivery, biosynthesis of heme (iron containing porphyrin), its regulation,
processes involved in its metabolism and describe porphyrin
functions in the body, disorders of heme biosynthesis (various types of porphyria's),
metabolism
catabolism of heme, various types of jaundice
Types of normal human hemoglobin, types of normal & abnormal derivatives of
6.12
hemoglobin, various hemoglobinopathies: Sickle cell anemia, Thalassemia
Describe the major types of hemoglobin and its derivatives
found in the body and their physiological/ pathological
relevance.
Competency No.
Topics & Subtopics
6.13
Describe the functions of the kidney, liver, thyroid and adrenal
1. Functions of liver, disorders& liver function tests
glands.
2. Functions of kidney, disorders& kidney function tests
6.14
Describe the tests that are commonly done in clinical practice
3.Functions of Thyroid, disorders& thyroid function tests
to assess the functions of these organs (kidney, liver, thyroid
4.Functions of Adrenals , disorders& Adrenal function tests
and adrenal glands).
6.15
Describe the abnormalities of kidney, liver, thyroid and adrenal
glands.
7
Molecular Biology
7.1
Structure and functions of nucleotides, biologically important nucleotides and their
Describe the structure and functions of DNA and RNA and
importance, major types of synthetic analogs of nucleotides (antimetabolites) and their
outline the cell cycle
clinical significance, structure and functions of DNA and RNA, Phases of cell cycle
7.2
Replication of DNA in Eukaryotes, inhibitors of DNA replication and different types of
Describe the processes involved in replication & repair of DNA
repair systems of DNA
and the transcription & translation mechanisms.
Transcription in Eukaryotes and posttranscriptional modifications, inhibitors, reverse
transcription & its significance
Genetic code and wobble hypothesis, Translation in Eukaryotes, inhibitors, chaperons ,
protein folding and posttranslational modifications
7.3
Causes and types of genetic mutations with examples.
Regulation of Eukaryotic gene expression
Competency No.
Topics & Subtopics
Describe gene mutations and basic mechanism of regulation of
gene expression
7.4
Recombinant DNA technology, restriction endonucleases, process of construction of
recombinant DNA and its applications in medicine, DNA library, blot transfer techniques-
Describe applications of molecular technologies like
southern blotting, northern blotting & western blotting, mechanism of polymerase chain
Recombinant DNA technology, PCR in the diagnosis and
reaction and its application in medical diagnosis and treatment of genetic diseases.
treatment of diseases with genetic basis.
Mechanisms of biotransformation of xenobiotics & associated diseases.
7.5
Describe the role of xenobiotics in disease
7.6
Enzymatic and non-enzymatic antioxidant defense systems in the body.
Describe the anti-oxidant defense systems in the body.
Free radical, biological sources of reactive oxygen species (ROS) and oxidative damage,
7.7
oxidative stress, roll of oxidative stress in cancer, diabetes mellitus & atherosclerosis.
Describe the role of oxidative stress in the pathogenesis of
conditions such as cancer, complications of diabetes mellitus
and atherosclerosis.
8
Nutrition
8.1
Importance of carbohydrates, lipids, proteins & vitamins, quality of proteins, various
Discuss the importance of various dietary components and
types of dietary fibers and their importance in the diet.
explain importance of dietary fiber.
Protein energy malnutrition, Kwashiorkor and Marasmus their causes and effects.
8.2
Describe the types and causes of protein energy malnutrition
and its effects.
Competency No.
Topics & Subtopics
Balanced diet in adult, in childhood and in pregnancy for optimal health, dietary advice in
8.3
diabetes mellitus & coronary heart disease
Provide dietary advice for optimal health in childhood and
adult, in disease conditions like diabetes mellitus, coronary
artery disease and in pregnancy.
Causes, effects and health risk associated with overweight/ obesity
8.4
Describe the causes (including dietary habits), effects and health
risks associated with being overweight/ obesity
Nutritional importance of commonly used items of food like cereals, pulses, eggs, meat,
8.5
fish, fruits and vegetables and their normal dietary requirements.
Summarize the nutritional importance of commonly used items
of food including fruits and vegetables (macro-molecules & its
importance)
9
Extracellular Matrix
Types & functions of the extracellular matrix (ECM), Components and functions of
9.1
proteoglycans, glycoproteins & major proteins of ECM
List the functions and components of the extracellular matrix
(ECM).
Disorders associated with components of ECM like Osteogenesis imperfecta, Marfan's
9.2
Syndrome , Mucopolysaccharidoses, Scurvy & Menkes Disease
Discuss the involvement of ECM components in health and
disease.
9.3
Types of protein targeting and sorting, disorders due to defects in mitochondrial
Describe protein targeting & sorting along with its associated
targeting signals and defects in peroxisomal matrix protein import.
disorders(It is non-core: N)
10
Oncogenesis and Immunity
Competency No.
Topics & Subtopics
10.1
Characteristics of cancer cell, molecular basis of cancer (carcinogenesis) ,various
carcinogens and initiator, promoter of carcinogens, oncogenes and proto-oncogenes,
Describe the cancer initiation, promotion oncogenes &
tumor suppressor genes (retinoblastoma, RB and p53), mechanisms of apoptosis in
oncogene activation. Also focus on p53 & apoptosis
physiologic and pathologic conditions .
10.2
Biochemical tumor markers, biochemical basis of chemotherapy, radiotherapy, hormonal
Describe various biochemical tumor markers and the
therapy, targeted drug therapy and immunotherapy.
biochemical basis of cancer therapy.
10.3
Cells of the Immune System, types of immune systems (Innate &adaptive), cellular and
Describe the cellular and humoral components of the immune
humoral components of innate and adaptive immune systems, B cell development and
system & describe the types and structure of antibody
the formation of antibodies, types, structure and mechanism of action of antibodies
(Immunoglobulins), primary and secondary response
10.4
Innate and adaptive immune systems, immunological memory, T lymphocytes
Describe & discuss innate and adaptive immune responses,
development, role of helper T cells (CD4+ T cells) and cytotoxic T cells/killer cells/CD8+ T
self/non-self-recognition and the central role of T-helper cells
cells in immune responses, Brief concept of MHC
in immune responses
Disorders ? Immunodeficiency, autoimmunity & hypersensitivity.
Antigens, concept involved in vaccine development and their types.
10.5
Describe antigens and concepts involved in vaccine
development.
11
Biochemical Laboratory Tests
11.1
Common lab equipments and apparatus like test tubes, pipettes & other glassware ,
Describe commonly used laboratory apparatus and equipments, auto pipettes, centrifuge, balances, oven, water bath good safe laboratory practice ,
good safe laboratory practice and waste disposal.
management of needle stick injury & latest guidelines of disposal of biomedical waste
Competency No.
Topics & Subtopics
11.2
Preparation of buffer ?acidic and alkaline. Measurement of pH paper and pH meter
Describe the preparation of buffers and estimation of pH.
11.3
Chemical constituents of normal urine
Describe the chemical components of normal urine.
11.4 & 11.20
Physical characteristics and organic constituents of urine.
11.4: Perform urine analysis to estimate and determine normal Collection of random & 24 hour urine sample
and abnormal constituents.
Urine Report: Physical characteristics and abnormal constituents, urine dipsticks
11.20: Identify abnormal constituents in urine; interpret the
Interpretation of Urine Abnormalities
findings and correlate these with pathological states.
11.5
Urine: Screening of inborn errors. Paper chromatography for diagnosis of inborn errors
Describe screening of urine for inborn errors & describe the use
of paper chromatography.
Club Paper chromatography of amino acid & TLC from
competency no 11.16
11.6
Colorimeter- Principle, Beer and Lambert's law & applications. Principles
Describe the principles of colorimetry.
of spectrophotometry.
(Club spectrophotometry from competency no 11.18)
11.7,11.8, 11.21 & 11.22
11.7- Demonstrate the estimation of serum creatinine and
Estimation of serum creatinine, urine creatinine and calculation of creatinine clearance and
creatinine clearance
their clinical interpretation.
11.8- Demonstrate estimation of serum proteins, albumin and
Estimation of serum proteins, albumin and calculation of A/G ratio and their clinical
A:G ratio
interpretation.
11.21- Demonstrate estimation of glucose, creatinine, urea and
total protein in serum.
11.22- Calculate albumin: globulin A:G ratio and creatinine
clearance
Estimation of plasma glucose, serum urea and their clinical interpretation.
11.9
Estimation of serum total cholesterol and HDL cholesterol, their ratio their clinical
interpretation.
Competency No.
Topics & Subtopics
Demonstrate the estimation of serum total cholesterol and HDL
cholesterol
11.10
Estimation of serum triglycerides and their clinical interpretation.
Demonstrate the estimation of triglycerides
11.11
Estimation of serum calcium and phosphorus their clinical interpretation.
Demonstrate estimation of calcium and phosphorous
11.12
Estimation of serum bilirubin: Total, direct and indirect, their clinical interpretation.
Demonstrate the estimation of serum bilirubin
11.13 & 2.2
Estimation of SGOT (AST)/ SGPT(ALT) and their clinical interpretation.
11.13- Demonstrate the estimation of SGOT/ SGPT
11.14
Estimation of serum ALP and their clinical interpretation.
Demonstrate the estimation of alkaline phosphatase
11.15
Physical characteristics and chemical composition of CSF
Describe & discuss the composition of CSF
11.16 &
Principle, application and working of following lab equipment's/techniques: pH meter,
11.19
paper chromatography of amino acids, protein electrophoresis, TLC, PAGE, Electrolyte
11.16- Observe use of commonly used equipment's/techniques analysis by ISE, ABG analyzer, ELISA, immunodiffusion, auto analyzer, quality control,
in biochemistry laboratory including:
DNA isolation from blood/tissue
?pH meter
?Paper chromatography of amino acid
(Paper chromatography of amino acid ,TLC clubbed with 11.5 )
?Protein electrophoresis
?TLC, PAGE
?Electrolyte analysis by ISE
?ABG analyzer
?ELISA
?Immunodiffusion
?Autoanalyser
?Quality control
Competency No.
Topics & Subtopics
? DNA isolation from blood/ tissue
11.19
Outline the basic principles involved in the functioning of
instruments commonly used in a biochemistry laboratory and
their applications.
11.17
Basis and rational of biochemical tests required in the following Conditions:
Explain the basis and rationale of biochemical tests done in the
-
Diabetes mellitus-blood & urine glucose, microalbumin, ketone bodies and
following conditions:
glycated hemoglobin ? (Club with 3.8 & 3.10)
-
diabetes mellitus,
-
dyslipidemia,
-
Dyslipidemia-lipid profile (Club with 4.5 & 4.7)
-
myocardial infarction,
-
renal failure, gout,
-
Myocardial infarction ?CK, LDH, Troponin (Club with 2.6 & 2.7)
-
proteinuria,
-
nephrotic syndrome,
-
Renal failure & nephrotic syndrome, ? BUN, Creatinine, urinary protein,
-
edema,
cholesterol
-
jaundice,
(Club with 3.8 & 3.10)
-
liver diseases, pancreatitis, disorders of acid- base
balance, thyroid disorders.
-
Gout- serum uric acid, synovial fluid analysis
(Club with 6.3 & 6.4)
-
liver diseases & Jaundice- LFTs (Club with 6.1) Pancreatitis- serum amylase and
lipase (Club with 2.5& 7 2.7)
Disorder of acid base balance- ABG analysis for pH, pO2, O2 saturation pCO2, HCO3 and
base excess (BE) (Club with 6.7,6.8)
-
Thyroid disorder ? serum free and total T3 & T4 and serum TSH (Club with 6.1)
11.18
Spectrophotometer ?principle & use
Discuss the principles of spectrophotometry.
(Clubbed with 11.6)
Competency No.
Topics & Subtopics
11.19
Instruments commonly used in Biochemistry laboratory & their applications.
Outline the basic principles involved in the functioning of
instruments commonly used in a Biochemistry laboratory and
their applications.
(Clubbed with & 11.6 & 11.16)
11.20
Identify abnormal constituents in urine, interpret the findings
and correlate these with pathological states. (Clubbed with
11.4)
11.21
Demonstrate estimation of glucose, creatinine, urea and total
protein in serum.
(Clubbed with 11.7, 11.8)
11.22
Calculate albumin: globulin (A/G)ratio and creatinine clearance
(Clubbed with 11.7, 11.8)
11.23
Energy contents of lipids, carbohydrates & proteins in common food items.
Calculate energy content of different food Items, identify food
items with high and low glycemic index and explain the
importance of these in the diet.
11.24
Advantages of unsaturated fats, disadvantages of saturated and trans fats in food
Enumerate advantages and/or disadvantages of use of
unsaturated, saturated and trans fats in food.
Paper wise distribution of topics
Organ function test
6.13-6.15
Molecular biology
7.1-7.3
Genetic engineering
7.4
Urine: Screening of inborn errors.
11.5
Principle, application and working of
11.16
following lab equipments/techniques: pH
meter, paper chromatography of amino
acids, protein electrophoresis,
TLC, PAGE, Electrolyte analysis by ISE,
ABG analyzer, ELISA, immunodiffusion,
auto analyzer, quality control, DNA
isolation from blood/tissue
For long answer question and scenario based / application questions,
topics will not be repeated.
Internal Assessment
Biochemisry
Applicable w.e.f August 2019 onwards examination for batches admitted from June 2019 onwards
S
I-Exam (December)
II-Exam (March )
Practical
Practical
(Including
(Including
05 marks
05 marks
Theory
Total
For
Theory
For
Total Marks
Journals
Marks
Journals
And
And
Log Book)
Log Book)
1
100
50
150
100
50
150
Preliminary Examinations
Remedial internal assessment examination for
Non - eligible students
III-Exam (July)
October
Practical
Including
Practical Including
10 Marks
10 Marks for
Total
Theory
Total Marks
Theory
for
Journal & Log
Marks
Journal &
Book
Log Book
200
100
300
200
100
300
1. There will be 3 internal assessment examinations in the academic year. The structure of Preliminary examinations
should be similar to the structure of University examination.
2. There will be only one additional examination for absent students (due to genuine reason) after approval by the
Committee Constituted for the same. It should be taken after preliminary examination and before submission of
internal assessment marks to the University.
3. First internal assessment examination will be held in December, second internal assessment examination will be held
in March and third internal assessment examination will be held in July.
4. Internal assessment marks for theory and practical will be converted to out of 40. Internal assessment marks, after
Conversion, should be submitted to university by 7th of August.
5. The student must secure at least 50% marks for total marks (combined in theory and practical / clinical: not less than
40% marks in theory and practical separately) assigned for internal assessment in a particular subject in order to be
eligible for appearing at the final university examination of that subject. Internal assessment marks will reflect as
separate head of passing at the summative examination.
6. Remedial internal assessment examination for Non - eligible students: Student who were not eligible due to less
than 50% combined or less than 40% in any theory or practical, will re appear as repeater student for Prelim exam
which will be conducted before Supplementary Exam. His/her internal assessment will be calculated on the basis of
this Examination marks only. Students who will not be eligible in this Examination will appear with regular batch as
repeater student.
7. The internal assessment marks of the remedial examination alone shall be considered and converted into out of 40.
8. Conversion Formula for calculation of marks in internal assessment examinations
Internal
assessment
Eligibility to appear for final University examination
First
Second
Third IA
marks:
(after conversion out of 40)
Total
IA
IA
(Prelim)
Conversion
(40% Separately in Theory and Practical, 50%
formula (out
Combined)
of 40)
Total marks obtained
Theory
100
100
200
400
16 (minimum)
10
Total of Theory + Practical
Total marks obtained
Must be 40.
Practical
50
50
100
200
16 (minimum)
5
9. Conversion formula for calculation of marks in Remedial internal assessment examination
Eligibility to appear for Supplementary
Remedial
Int. Assess. marks conversion
Exam. (after conversion out of 40 )
Exam
formula (out of 40)
(40% Separately in Theory and Practical,
(Prelim)
50% Combined)
Total marks obtained
Theory
200
16
5
(minimum)
Total of Theory +
Practical Must be
Total marks obtained
Practical
100
16 (minimum)
40.
2.5
While preparing Final Marks of Internal Assessment, the rounding-off marks shall done as illustrated in following table
Internal Assessment Marks
Final rounded marks
15.01 to 15.49
15
15.50 to 15.99
16
First Year MBBS Practical Mark's Structure Internal Assessment Examinations I & II (Applicable for batch admitted
in M.B.B.S Course from Academic Year 2019-20 & onwards)
Biochemistry
Practical
Oral/Viva
Total
Quantitative
Seat
Quantitative
Journal/
Experiment/Urine organic/Urine Report/Quality
Spots
No.
Experiment
Logbook
Control/Interpolation of lab Report /Interpolation of Special
Technique
A
B
C
D
E
F
Max.
Marks
15
15
5
5
10
50
First Year MBBS Practical Marks Structure (Prelim)
(Applicable w.e.f August 2019 onwards examination for batches admitted from June 2019 onwards)
Biochemistry
Case Based
Interpretation of lab
Viva
Practical/Viva
Urine Report/ Quantitative
Quality
Journal &
Practical
Seat
Quantitative
Reports & special
Spots
Voce/ Oral
Total
estimation
Control
Logbook
Total
No
Estimation
techniques
Marks
(Minimum 2
Interpretation)
A
B
C
D
E
F
G
H
I
Max.
25
15
10
20
10
10
90
10
100
Marks
(Please Note - The above examination pattern will be applicable to the students admitted from Academic Year 2019-20 and onwards, which is informed to all Medical
Colleges vide University letter No MUHS /X-1 /UG /1692 /2020 Date: 28/02/2020)
First Year MBBS Practical Marks Structure (MUHS Exam)
(Applicable w.e.f August 2019 onwards examination for batches admitted from June 2019 onwards)
Biochemistry
Case Based
Interpretation of lab
Viva
Practical/Viva
Urine Report/ Quantitative
Quality
Practical
Seat
Quantitative
Reports & special
Spots
Voce/ Oral
Total Marks
estimation
Control
Total
No
Estimation
techniques
(Minimum 2
Interpretation)
A
B
C
D
E
F
G
H
Max.
25
15
10
20
10
80
20
100
Marks
(Please Note - The above examination pattern will be applicable to the students admitted from Academic Year 2019-20 and onwards, which is informed to all Medical
Colleges vide University letter No MUHS /X-1 /UG /1692 /2020 Date: 28/02/2020)
MAHARASHTRA UNIVERSITY OF HEALTH SCIENCES, NASHIK
FORMAT / SKELETON OF QUESTION PAPER
1. Course and Year : First MBBS
2. Subject Code
: Appendix - a
(applicable w.e.f. Sept. 2020& onwards examinations)
3. Subject (PSP)
: Anatomy / Physiology / Biochemistry
(TT)
:
4. Paper :
: I
5. Total Marks
: 100
6. Total Time
: 3 Hrs.
7. Remu. (PS)
: Rs. 300/-
8. Remu. (PM)
: Rs. 350/-
9. Web Pattern
: [ ]
10. Web Skeleton
: [ ]
11. Web Syllabus
: [ ]
12. Web Old QP
: [ ]
SECTION "A" MCQ
Instructions:
1)
Fill (dark) the appropriate empty circle below the question number once only.
2)
Use blue/black ball point pen only.
3)
Each Question carries One mark.
4)
A student will not be allotted any marks if he/she overwrites, strikes out or puts white ink on the circle once filled
(darkened)
5)
Do not write anything on the blank portion of the question paper if written anything, such type of act will be considered as
an attempt to resort to unfair means.
SECTION "A" MCQ (20 Marks)
Q1. Multiple Choice Questions (Total 20 MCQ of One mark each) (4 MCQ Should be clinical application based)
(20x1=20)
a) b) c) d) e) f) g) h) i) j)
k) l) m) n) o) p) q) r) s) t)
SECTION "B"
Instructions: 1) Use blue/black ball point pen only.
2) Do not write anything on the blank portion of the question paper. If written anything, such type of act will be considered as an
attempt to resort to unfair means.
3) All questions are compulsory.
4) The number to the right indicates full marks.
5) Draw diagrams wherever necessary.
6) Distribution of syllabus in Question Paper is only meant to cover entire syllabus within the stipulated frame. The Question paper
pattern is a mere guideline. Questions can be asked from any paper's syllabus into any question paper. Students cannot claim
that the Question is out of syllabus. As It is only for the placement sake, the distribution has been done.
7) Use a common answerbook for all sections.
SECTION "B" (80 Marks)
2.
Brief answer questions (Any Ten out of Eleven)
(10x 2= 20)
a)
b) c) d) e) f) g) h) i) j) k)
3.
Short Answer Questions (Any Eight out of Nine)
(8x5= 40)
One SAQ has to be on AETCOM Module (For Anatomy 1.1, 1.5, For Physiology 1.2.,1.3&For Biochemistry,
1.4) & Minimum 2 SAQs should be Case Based Questions/ Clinically applied Questions.
a)
b) c) d) e) f) g) h) i)
4.
Long Answer Questions (Any Two out of Three)
(2x 10= 20)
a)
b) c)
Note: All questions should be structured .Wherever necessary; split up of marks should be specified.
MAHARASHTRA UNIVERSITY OF HEALTH SCIENCES, NASHIK
FORMAT / SKELETON OF QUESTION PAPER
1.
Course and
: First MBBS
2. Subject Code
: Appendix - a
Year
(applicable w.e.f. Sept. 2020& onwards examinations)
3. Subject (PSP)
: Anatomy / Physiology / Biochemistry
(TT)
:
4. Paper :
: II
5. Total Marks
: 100
6. Total Time
: 3 Hrs.
7. Remu. (PS)
: Rs. 300/-
8. Remu. (PM)
: Rs. 350/-
9. Web Pattern
: [ ]
10. Web Skeleton
: [ ]
11. Web Syllabus
: [ ]
12. Web Old QP
: [ ]
Instructions:
SECTION "A" MCQ
1)
Fill (dark) the appropriate empty circle below the question number once only.
2)
Use blue/black ball point pen only.
3)
Each Question carries One mark.
4)
A student will not be allotted any marks if he/she overwrites, strikes out or puts white ink on the circle once filled (darkened)
5)
Do not write anything on the blank portion of the question paper if written anything, such type of act will be considered as
an attempt to resort to unfair means.
SECTION "A" MCQ (20 Marks)
1. Multiple Choice Questions (Total 20 MCQ of One mark each) (4 MCQ Should be clinical application based)
(20x1=20)
a) b) c) d) e) f) g) h) i) j)
k) l) m) n) o) p) q) r) s) t)
SECTION "B"
Instructions: 1) Use blue/black ball point pen only.
2) Do not write anything on the blank portion of the question paper. If written anything, such type of act will be considered as an
attempt to resort to unfair means.
3) All questions are compulsory.
4) The number to the right indicates full marks.
5) Draw diagrams wherever necessary.
6) Distribution of syllabus in Question Paper is only meant to cover entire syllabus within the stipulated frame. The Question paper
pattern is a mere guideline. Questions can be asked from any paper's syllabus into any question paper. Students cannot claim that
the Question is out of syllabus. As It is only for the placement sake, the distribution has been done.
7) Use a common answer book for all sections.
SECTION "B" (80 Marks)
2.
Brief answer questions (Any Ten out of Eleven)
(10x 2= 20)
a)
b) c) d) e) f) g) h) i) j) k)
3.
Short Answer Questions (Any Eight out of Nine)
(8x5= 40)
Minimum 2 SAQs should be Case Based Questions/ Clinically applied Questions.
4.
a)
b) c) d) e) f) g) h) i)
(2x 10= 20)
Long Answer Questions (Any Two out of Three)
a) b) c)
Note: All questions should be structured .Wherever necessary, split up of marks should be specified.
MAHARASHTRA UNIVERSITY OF HEALTH SCIENCES, NASHIK
MARKLIST FOR PRACTICAL / ORAL / VIVA VOCE
(Summer / Winter ? 20...Exam (MBBS UG Courses)
(Applicable for batch admitted in M.B.B.S Course from Academic Year 2019-20 & onwards)
Course : FIRST MBBS Subject : Biochemistry
CENTRE : Marks : (Practical = Practical/Clinical + Viva ) Min. 50 Max. 100
Date : / /20 Batch :
Practical
Oral/Viva
Total
Seat
Case Based
Urine Report/
Quality
Interpretation of lab Report &
Spots
Practical
Viva Voce/Oral
Practical/Viva
No.
Quantitative
Quantitative
Control
special techniques
(Total)
Total
Total
Estimation
estimation
( Minimum 2 interpretations)
Marks
A
B
C
D
E
F
G
H
Max.
25
15
10
10
80
20
100
Marks
20
Note : Both Examiners should jointly conduct practical examination for each student.
Verified above entries from Answerbooks and we hereby certify that the marks entered against each Seat Number are found correct.
NAME OF EXAMINER
COLLEGE
SIGNATURE WITH DATE
1
Convenor
2
Internal
3
External
4
External
BOOKS RECOMMENDED:
TEXT BOOKS ;
1. Medical Biochemistry - U.Satyanarayan.
2. Biochemistry for Medical students by D.M.Vasudevan & Shree Kumari.
3. Medical Biochemistry by M.N. Chatterjea and Rana Shinde.
4. Text Book of Medical Biochemistry by Ramakrishnan, Prasannan & Rajan.
5. Medical Biochemistry by Debajyoti Das.
6. Biochemistry by A.C.Deb.
REFERENCE BOOKS:
1. Biochemistry by Pankaja Naik
2. Harper's Biochemistry.
3. Medical Biochemistry by N.V.Bhagwan.
4. Biochemistry by L.Stryer.
5. Biochemistry by Orten & Neuhans.
6.Text Book of Biochemistry for Medical Student-8th Edition-16 By- DM Vasudevan
This post was last modified on 29 June 2021