Date: 06-10-2014 BR 5005
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours Max Marks: 50
Instructions: 1. Answer to the points. 2. Figure to the

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right indicates marks. 3. Use separate answer books
for each section. 4. Draw diagrams wherever
necessary. 5. Write legibly.
Section 1
1. Give an account of: (any two) (10)

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a. Blood buffers and its importance (A. 398) (C.
475)
b. Hyperbilirubinemia (A. 330) (C. 214)
c. Diagnostic importance of Enzymes assay
2. Write Short notes on (any three) (9)

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a. Prostaglandins (A. 243) (C.644)
b. Competitive inhibition (A. 63) (C.92)
c. Sickle cell anaemia
d. Mucopolysaccharides and its disorders (A.
98) (C.22)

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3. Write Short notes on (any two) (6)
a. Chromatography (A. 434) (C.719)

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b. Renal function test (RFT) (A. 370) (C. 459)
c. Active transport (A. 15) (C. 651)
Section 2

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1. Give an account on (any two) (10)
a. Metabolism of low density lipoprotein and
high density lipoprotein
b. Effect of hormones on glucose level in blood
c. Significance and regulation of

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gluconeogenesis (A. 135) (C.258)
2. A. Write Short notes on (any three) (9)
a. Cell mediated immunity
b. Toxic substances in food stuffs
c. High energy compounds

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d. Tumour markers (A. 666) (C.691)
e. Lipid peroxidation
3. Read the following case and answer any six
question in two to threee lines :A 40 years old
woman admitted with recurrent pain in the

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abdomen developed jaundice (6) two days after
admission. History revealed that the pain often
aggravated after intake of fatty food. Routine
urine examination showed the presence of bile
pigments and bile salts urobilinogen was absent.

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Blood report revealed very high levels of
conjugated bilirubin.

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a. What is the most likely cause?
b. What is the type of jaundice? (A. 332) (C.
216)

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c. Enumerate causes of this type of jaundice
d. Explain findings in urine
e. Explain reason for high levels of conjugated
bilirubin
f. Which other tests will be reformed in the

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patient?
g. What is the normal range of total
unconjugated and conjugated bilirubin in
blood/serum?
h. Name two inherited disorders of bilirubin

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metabolism in which jaundice occurs
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