First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
Max Marks: 50
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Date: 06-12-2014Instructions: 1. Answer to the points. 2. Figure to the right
indicates marks. 3. Use separate answer books for each section.
4. Draw diagrams wherever necessary. 5. Write legibly.
Section 1
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1. Give an account of: (any two) (10)a. Role of folic acid and vitamin B12 in body
b. Polymerase chain reaction technique & its application
c. Urea cycle & its disorders
2. Write Short notes on (any three) (9)
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a. Structure and types of DNAb. Replication fork
c. Initiation of protein synthesis
d. Genetic code and its characteristics
e. Restriction fragment length polymorphism
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3. Write Short notes on (any two) (6)a. Proteins nutritional importance & malnutrition
b. Various roles of Acetyl CoA
c. Blotting techniques
Section 2
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1. Give an account on (any two) (10)a. Denaturation of protein
b. Iron deficiency
c. Disposal of ammonia
2. A. Write Short notes on (any three) (9)
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a. Methyl folate trapb. Pellagra
c. Gout
d. Antioxidant vitamins
e. Biochemical role of cholecalciferol
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3. Write Short notes of (any six):A 70 year old man presented withback pain loss of weight and breathless. Om examination, he
was anemic Investigations showed. Hb- (6) 8 g/dl: Serum total
proteins 20.5 g/dl: S albumin - 3 g/dl: B. Urea 50-mg/dl: S
Creatinine - 3 mg/dl. Scrum Protein electrophoresis showed m
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band in gamma region. In urine Bence Jones proteins werepresent.Radiological examination showed punched out lytic
lesions in lumber vertebrae, ribs and pelvis
a. What is the likely diagnosis?
b. Name various other condition which alter A: G ratio.
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c. What is principle of electrophoresis?d. How are paraproteins (Myeloma proteins) Different from normal
immunoglobulin molecules?
e. What are Bence Jones proteins? How are they detected in
urine?
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