I MBBS Biochemistry Paper 2
Date: 06-12-2017
Time: 3 hours
Max Marks: 50
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Instructions: 1. Answer to the points. 2. Figureto the right indicates marks. 3. Use separate
answer books for each section. 4. Draw
diagrams wherever necessary. 5. Write legibly.
Section 1
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1.Give an account of: (any two) (10)a. Causes and deficiency manifestations of
Vitamin B12
b. Homocystinuria and transmethylation
reactions
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c. DNA repair mechanisms (A. 562) (C. 537)2.Write Short notes on (any three) (9)
a. Telomere and function of telomerase
b. Causes of primary Gout and its treatment
policies (A. 548) (C. 394)
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c. Use of radioisotopes in medicine (A. 682) (C.717)
d. Applications of Recombinant DNA technology
(A. 600) (C. 579)
e. Post transcriptional modification (A. 572) (C.
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547)3.Write Short notes on (any two) (6)
a. Glycemic index
b. Metabolic adaption in fed and starvation
condition (A. 122) (C. 383)
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c. Kwashiorkor and associated metabolicalterations
Section 2
4.Give an account on (any two) (10)
a. Sources, absorption transport functions and
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disorders of calcium (A. 492)(C. 404)b. Enumerate antioxidant vitamins and explain
their role as antioxidant (A. 429) (C. 659)
c. Explain sulphur containing amino acids (A.
275) (C.361)
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5.Write Short notes on (any three) (9)a. Sources of purine formation
b. Phenylketonuria (A. 292) (C. 351)
c. Salvage pathway (A. 546) (C. 391)
d. Functions of copper in body
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e. Niacin6.Read the case report and answer the
following Questions (any six) : A 3 year old boy
was admitted to pediatric ward of a a-
government hospital due to pain in (6)
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abdomen. He has severe palor of skin, whichprompted pediatrician to order his hemoglobin
estimation in the laboratory, it was 3 gm %
considering his tribal origin,
possibility of sickle cell disease was suspected.
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Laboratory was requested to test his blood forthe possibility of sickle cell disease. Patient's
hemoglobin was found
insoluble in low oxygen solution.
Electrophoresis showed that the patient had
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only HbS while both parents had HbS and HbAa. Write primary structural defect in the patient's
hemoglobin
b. Why the patients had Hemolytic anamia?
c. Why the patient's hemoglobin was not soluble
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in low oxygen solution?d. Why HbS move slower towards anode during
electrophoresis at PH 8.6?
e. Why the patient did not suffer from anaemia
right from the birth?
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f. Which are the other abnormal hemoglobin?g. HbF has a high affinity for 02 than HibA
h. Why sickle cell disease carriers' have an
advantage in surviving malarial parasite?
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