First Year MBBS Examination
I MBBS Biochemistry Paper 2
Date: 06-12-2017
Time: 3 hours
Max Marks: 50
to the right indicates marks. 3. Use separate
answer books for each section. 4. Draw
diagrams wherever necessary. 5. Write legibly.
Section 1
a. Causes and deficiency manifestations of
Vitamin B12
b. Homocystinuria and transmethylation
reactions
2.Write Short notes on (any three) (9)
a. Telomere and function of telomerase
b. Causes of primary Gout and its treatment
policies (A. 548) (C. 394)
717)
d. Applications of Recombinant DNA technology
(A. 600) (C. 579)
e. Post transcriptional modification (A. 572) (C.
3.Write Short notes on (any two) (6)
a. Glycemic index
b. Metabolic adaption in fed and starvation
condition (A. 122) (C. 383)
alterations
Section 2
4.Give an account on (any two) (10)
a. Sources, absorption transport functions and
b. Enumerate antioxidant vitamins and explain
their role as antioxidant (A. 429) (C. 659)
c. Explain sulphur containing amino acids (A.
275) (C.361)
a. Sources of purine formation
b. Phenylketonuria (A. 292) (C. 351)
c. Salvage pathway (A. 546) (C. 391)
d. Functions of copper in body
6.Read the case report and answer the
following Questions (any six) : A 3 year old boy
was admitted to pediatric ward of a a-
government hospital due to pain in (6)
prompted pediatrician to order his hemoglobin
estimation in the laboratory, it was 3 gm %
considering his tribal origin,
possibility of sickle cell disease was suspected.
the possibility of sickle cell disease. Patient's
hemoglobin was found
insoluble in low oxygen solution.
Electrophoresis showed that the patient had
a. Write primary structural defect in the patient's
hemoglobin
b. Why the patients had Hemolytic anamia?
c. Why the patient's hemoglobin was not soluble
d. Why HbS move slower towards anode during
electrophoresis at PH 8.6?
e. Why the patient did not suffer from anaemia
right from the birth?
g. HbF has a high affinity for 02 than HibA
h. Why sickle cell disease carriers' have an
advantage in surviving malarial parasite?
***
I MBBS Biochemistry Paper 2
Date: 06-12-2017
Time: 3 hours
Max Marks: 50
--- Content provided by FirstRanker.com ---
Instructions: 1. Answer to the points. 2. Figureto the right indicates marks. 3. Use separate
answer books for each section. 4. Draw
diagrams wherever necessary. 5. Write legibly.
Section 1
--- Content provided by FirstRanker.com ---
1.Give an account of: (any two) (10)a. Causes and deficiency manifestations of
Vitamin B12
b. Homocystinuria and transmethylation
reactions
--- Content provided by FirstRanker.com ---
c. DNA repair mechanisms (A. 562) (C. 537)2.Write Short notes on (any three) (9)
a. Telomere and function of telomerase
b. Causes of primary Gout and its treatment
policies (A. 548) (C. 394)
--- Content provided by FirstRanker.com ---
c. Use of radioisotopes in medicine (A. 682) (C.717)
d. Applications of Recombinant DNA technology
(A. 600) (C. 579)
e. Post transcriptional modification (A. 572) (C.
--- Content provided by FirstRanker.com ---
547)3.Write Short notes on (any two) (6)
a. Glycemic index
b. Metabolic adaption in fed and starvation
condition (A. 122) (C. 383)
--- Content provided by FirstRanker.com ---
c. Kwashiorkor and associated metabolicalterations
Section 2
4.Give an account on (any two) (10)
a. Sources, absorption transport functions and
--- Content provided by FirstRanker.com ---
disorders of calcium (A. 492)(C. 404)b. Enumerate antioxidant vitamins and explain
their role as antioxidant (A. 429) (C. 659)
c. Explain sulphur containing amino acids (A.
275) (C.361)
--- Content provided by FirstRanker.com ---
5.Write Short notes on (any three) (9)a. Sources of purine formation
b. Phenylketonuria (A. 292) (C. 351)
c. Salvage pathway (A. 546) (C. 391)
d. Functions of copper in body
--- Content provided by FirstRanker.com ---
e. Niacin6.Read the case report and answer the
following Questions (any six) : A 3 year old boy
was admitted to pediatric ward of a a-
government hospital due to pain in (6)
--- Content provided by FirstRanker.com ---
abdomen. He has severe palor of skin, whichprompted pediatrician to order his hemoglobin
estimation in the laboratory, it was 3 gm %
considering his tribal origin,
possibility of sickle cell disease was suspected.
--- Content provided by FirstRanker.com ---
Laboratory was requested to test his blood forthe possibility of sickle cell disease. Patient's
hemoglobin was found
insoluble in low oxygen solution.
Electrophoresis showed that the patient had
--- Content provided by FirstRanker.com ---
only HbS while both parents had HbS and HbAa. Write primary structural defect in the patient's
hemoglobin
b. Why the patients had Hemolytic anamia?
c. Why the patient's hemoglobin was not soluble
--- Content provided by FirstRanker.com ---
in low oxygen solution?d. Why HbS move slower towards anode during
electrophoresis at PH 8.6?
e. Why the patient did not suffer from anaemia
right from the birth?
--- Content provided by FirstRanker.com ---
f. Which are the other abnormal hemoglobin?g. HbF has a high affinity for 02 than HibA
h. Why sickle cell disease carriers' have an
advantage in surviving malarial parasite?
***
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