Date: 01-04-2016
GDV 2805
Second Year MBBS Examination
II MBBS Pharmacology Paper 1
Time: 2 hours
2. Figure to the right indicates marks.
3. Use separate answer books for each section.
4. Draw diagrams wherever necessary.
5. Write legibly.
Max Marks: 40
1. MCQ (10)
a) AdmMinisiention of antacid reduces action of
the following antiulcer agent:a) Omeprazole b)
b) Which one of the following statements, about
the metabolism of local anesthetics is
incorrect? a) Metabolism of local anesthetics
occurs at the site of administration
b)Metabolism, occurs in the. plasma or liver but
not at the site. of administration c) Ester group
of anesthetics like procaine, are metabolized
systematically by pseudocholinesterase d)
Amides such as lidocaine, are metabolized in
oxidases.
c) Therapeutic drug monitoring is done for all
EXCEPT a) High safety margin drugs b) Toxic
drugs (C) Failure to response d) For patient
d) Which receptor is not a type of GPCR (G-
protein coupled receptor)? (A) Muscarinic
Receptors (B) Nicotinic Receptors c) alpha
Receptors d) Beta Receptor
Direct action on the GABA receptor-chloride
channel complex (B) Inhibition of GABA
aminotransferase c)NMDA receptor blockade
via the glycine binding site (D) Inhibition of
f) Sumatriptan is a:(A) 5 HT1D1B antagonist.
(B) 5 HT 181C agonist C) 5 HT 1A1D
antagonist D) S HT 181D agonist
g) Which antidepressants is a nonselective
MAO inhibitor? (A) Moclobemide (B) Fluoxetine
(C) Tranyleypromine(D) Selegiline
h) Which of the following statements
concerning the anti-inflammatory effect of
NSAIDs are true?(A) Anti-inflammatory effect of
cyclooxygenase(B) Anti-inflammatory effect of
NSAIDs results from inhibition of phospholipase
A2-> and reducing prostaglandin and
leukotriene synthesis(C) Anti- inflammatory
cyclooxygenase II expression which results in
reducing the amount of an enzyme available to
produce prostoglandins d) All of the above
i) Toxicity of digitalis is increased by(A)
Hypermagnesemia (D) Hypocalcemia
j) Amiloride cause hyperkalemia due to its
action on: (A) Electronic K* channels b)
Blectranic Na channels (C) Non electronic Kt-Cl
Section 2
2. short notes on: (two out of three) (10)
a) treatment of methanol poisoning
b) Treatment of paracetamol poisoning
3. Write briefly on: (four out of five) (10)
a) Prostaglandins: analogues used in glaucoma
b) Potassium channel openers
c) Enzyme Induction
e) COMT inhibitors
4. Write short notes on: (two out of three)
(10)
a) Central sympatholytics
c) Atypical antipsychotics
***
GDV 2805
Second Year MBBS Examination
II MBBS Pharmacology Paper 1
Time: 2 hours
--- Content provided by FirstRanker.com ---
1. Answer to the points.2. Figure to the right indicates marks.
3. Use separate answer books for each section.
4. Draw diagrams wherever necessary.
5. Write legibly.
--- Content provided by FirstRanker.com ---
Section 1Max Marks: 40
1. MCQ (10)
a) AdmMinisiention of antacid reduces action of
the following antiulcer agent:a) Omeprazole b)
--- Content provided by FirstRanker.com ---
Sucralfate c)Misoprostol d)Pirenzepineb) Which one of the following statements, about
the metabolism of local anesthetics is
incorrect? a) Metabolism of local anesthetics
occurs at the site of administration
--- Content provided by FirstRanker.com ---
b)Metabolism, occurs in the. plasma or liver but
not at the site. of administration c) Ester group
of anesthetics like procaine, are metabolized
systematically by pseudocholinesterase d)
Amides such as lidocaine, are metabolized in
--- Content provided by FirstRanker.com ---
the liver by microsomal mixed functionoxidases.
c) Therapeutic drug monitoring is done for all
EXCEPT a) High safety margin drugs b) Toxic
drugs (C) Failure to response d) For patient
--- Content provided by FirstRanker.com ---
complianced) Which receptor is not a type of GPCR (G-
protein coupled receptor)? (A) Muscarinic
Receptors (B) Nicotinic Receptors c) alpha
Receptors d) Beta Receptor
--- Content provided by FirstRanker.com ---
e) The mechanism of action of vigabatrin:(A)Direct action on the GABA receptor-chloride
channel complex (B) Inhibition of GABA
aminotransferase c)NMDA receptor blockade
via the glycine binding site (D) Inhibition of
--- Content provided by FirstRanker.com ---
GABA neuronal reuptakef) Sumatriptan is a:(A) 5 HT1D1B antagonist.
(B) 5 HT 181C agonist C) 5 HT 1A1D
antagonist D) S HT 181D agonist
g) Which antidepressants is a nonselective
--- Content provided by FirstRanker.com ---
MAO inhibitor? (A) Moclobemide (B) Fluoxetine
(C) Tranyleypromine(D) Selegiline
h) Which of the following statements
concerning the anti-inflammatory effect of
NSAIDs are true?(A) Anti-inflammatory effect of
--- Content provided by FirstRanker.com ---
NSAIDs results from inhibition ofcyclooxygenase(B) Anti-inflammatory effect of
NSAIDs results from inhibition of phospholipase
A2-> and reducing prostaglandin and
leukotriene synthesis(C) Anti- inflammatory
--- Content provided by FirstRanker.com ---
effect of NSAIDs results from induction ofcyclooxygenase II expression which results in
reducing the amount of an enzyme available to
produce prostoglandins d) All of the above
i) Toxicity of digitalis is increased by(A)
--- Content provided by FirstRanker.com ---
Hypokalemia (B) Hyperkalemia(C)Hypermagnesemia (D) Hypocalcemia
j) Amiloride cause hyperkalemia due to its
action on: (A) Electronic K* channels b)
Blectranic Na channels (C) Non electronic Kt-Cl
--- Content provided by FirstRanker.com ---
symporter (D) Ht "Kt ATPaseSection 2
2. short notes on: (two out of three) (10)
a) treatment of methanol poisoning
b) Treatment of paracetamol poisoning
--- Content provided by FirstRanker.com ---
c) Pharmacotherapy of chronic gout3. Write briefly on: (four out of five) (10)
a) Prostaglandins: analogues used in glaucoma
b) Potassium channel openers
c) Enzyme Induction
--- Content provided by FirstRanker.com ---
d) Centrally acting muscle relaxantse) COMT inhibitors
4. Write short notes on: (two out of three)
(10)
a) Central sympatholytics
--- Content provided by FirstRanker.com ---
b) Receptor antagonismc) Atypical antipsychotics
***