Date: 05-01-2023
MCT 7012
Second Year MBBS Examination
II MBBS Pharmacology Paper 2 (New)
Time: 3 hours Max Marks: 100

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Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each section.
4. Draw diagrams wherever necessary.

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5. Write legibly.
Section 1
1. Structured long questions:Write briefly on:
(any one out of two) (10)
a. Classify antitubercular drugs. Describe the

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mechanism of action and adverse effects of
first line antitubercular drugs.
b. Classify Penicillins. Describe the mechanism
of action, antibacterial spectrum, therapeutic
uses and adverse effects of Penicillin-G.

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2. Case base scenario/applied short notes:Write

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short notes on: (any two out of three) (12)
3. Write short notes: (any three out of four) (18)
a. Albendazole.
b. Mechanism of action, therapeutic uses and

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adverse effects of Metronidazole.
c. Linezolid.
d. Mechanism of action and side effects of
aminoglycosides.
4. Answer in 2-3 sentences: Explain briefly with

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reason: (any five out of six) (10)
a. Justify the rationale of combining imipenem
with cilastatin.
b. Write two therapeutic uses and two adverse
effects of amphotericin B.

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c. Name four antibacterial] drugs that affect
bacterial protein synthesis.
d. Ethambutol should be used with Precaution in
children. Justify.
e. Write two drugs causing Disulfiram like

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reaction.
f. What is lepra reaction? How will you treat this
reaction?

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Section 2
1. Structured long question: Write briefly on: (any

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one out of two) (10)
a. Classify drugs for bronchial asthma. Describe
the pharmacological action, mechanism of
action, adverse effects and drug interactions
of theophylline.

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b. Describe different insulin preparation,
pharmacological action, uses and adverse
effects of insulin.
2. 5A.Case base scenario / applied short
notes:Write short notes on: (any two out of

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three) (12)
a. A 35-year-old man has come with complaint
of acute onset diarrhoea. The stools are
relatively small volume, liquid but not watery,
frothy and are preceded by griping pain in

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abdomen. Foul smelling wind, eructation and
mild fever are the other complaints. He has
passed 4 loose motions in the past 8 hours
and there is no appetite. He admits to have
eaten spicy snacks last evening at a road

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side stall. Physical examination reveals body
temperature 101?F, no signs of dehydration,
but diffuse abdominal tenderness: A tentative
diagnosis of enteroinvasive diarrhoea is
made.(a) Does this patient require

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rehydration therapy? (b) Should an antibiotic

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be prescribed ? If so, which antibiotic would
be appropriate ? (c) Should an antimotility-
antidiarrhoeal drug be coprescribed to reduce
the number of stools ?(d) Should any other

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symptomatic drug be given to him?
b. A full term primigravida aged 26 years is
brought to the hospital with the complaint of
having labour pains for the past 24 hours
without making much progress. Two hours

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ago she had passed meconium stained
liquor. The lady is in distress, mildly
dehydrated and looks exhausted. The
presentation is vertex and head is engaged,
but cervix is incompletely dilated and uterine

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contractions are relatively weak. Foetal
tachycardia is noted with irregularity during
contractions. (a) What course of action is
appropriate? (b) Can she be administered a
uterine stimulant to strengthen the

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contractions? If yes, which drug should be
given and how? If no, then why?
c. A 35 years old male patient is having dry
cough since 3 days. Physician prescribed the
drug fot &foethe relief from cough. Patient

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complained of constipation after taking the
drug. (a) Write two cough suppressant drugs.
(b) Mention the mechanism of action and two
adverse effects of prescribed drug. (c) Why
patient complained of constipation?

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3. 58.Write short notes: (any three out of four)
(18)
a. 5-HT 38 antagonists.
b. Selective estrogen receptor
modulators(SERMs).

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c. Therapeutic uses and side effects of
corticosteroids.
d. Bisphosphonates.
4. 6.Answer in 2-3 sentences: Explain briefly with
reason (any five out of six) (10)

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a. Name two tocolytics with their uses.
b. Write pharmacological basis of ipratropium
bromide in COPD.
c. Write two chelating agents with their uses.
d. Write the mechanism of action of

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omalizumab.
e. Give two examples of osmotic purgative and
Stool softener.
f. Write mechanism of action and two side
effects of propylthaiouracil.

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