FirstRanker Logo

FirstRanker.com - FirstRanker's Choice is a hub of Question Papers & Study Materials for B-Tech, B.E, M-Tech, MCA, M.Sc, MBBS, BDS, MBA, B.Sc, Degree, B.Sc Nursing, B-Pharmacy, D-Pharmacy, MD, Medical, Dental, Engineering students. All services of FirstRanker.com are FREE

📱

Get the MBBS Question Bank Android App

Access previous years' papers, solved question papers, notes, and more on the go!

Install From Play Store

Download MBBS Diabetes Mellitus Lecture PPT

Download MBBS (Bachelor of Medicine and Bachelor of Surgery) Latest Diabetes Mellitus Lecture PPT

This post was last modified on 30 November 2021


Diabetes Mellitus

Diabetes mellitus (DM) comprises a group of

--- Content provided by FirstRanker.com ---

metabolic disorders presenting with

hyperglycaemia resulting from insulin deficiency or

decreased glucose utilization and increased glucose

--- Content provided by FirstRanker.com ---


production.
TYPES OF DIABETES MELLITUS.

TYPE- I DIABETES MELLITUS.

--- Content provided by FirstRanker.com ---



? Type I diabetes mellitus is due to pancreatic B-cell

destruction leading to insulin deficiency.

--- Content provided by FirstRanker.com ---


? It is more common in children, adolescents and young

adults usually below 30 years.

--- Content provided by FirstRanker.com ---


? Insulin is usually required for treatment i.e. patients

are insulin dependent.

--- Content provided by FirstRanker.com ---

? These subjects are genetically susceptible and are

prone to develop ketosis.

? Due to the above features, this diabetes is also

--- Content provided by FirstRanker.com ---


called brittle diabetes.
Type II Diabetes mellitus.

? Type II Diabetes Mellitus is characterized by

--- Content provided by FirstRanker.com ---


variable degree of insulin resistance, and impaired

insulin secretion.

--- Content provided by FirstRanker.com ---

? It is preceded by a period of abnormal glucose

homeostasis classified as impaired fasting glucose

(IFG) or impaired glucose tolerance (IGT).

--- Content provided by FirstRanker.com ---



? Typically, it develops with increasing age.

? However, age in no bar and can also occur in

--- Content provided by FirstRanker.com ---

obese children and adolescents.
Gestational Diabetes.

? Insulin resistance seen in late pregnancy may lead

--- Content provided by FirstRanker.com ---

to impaired glucose tolerance and even frank

diabetes called gestational diabetes mellitus.


--- Content provided by FirstRanker.com ---


? Most subjects revert to normal glucose
tolerance after delivery but have increased
risk (=~60%) of developing diabetes mellitus in

--- Content provided by FirstRanker.com ---

future (10-20 years).


METABOLIC CHANGES IN DIABETES

--- Content provided by FirstRanker.com ---

MELLITUS.

? Hyperglycemia--

1.overproduction of glucose by gluconeogenesis.

--- Content provided by FirstRanker.com ---


2.under utilization of glucose by the tissues due to insulin

deficiency.

--- Content provided by FirstRanker.com ---

? Lypolysis-- Low insulin : glucose ratio.

? KETOSIS and Hyperlipidemia- Acetyl-Co A diverted to other

pathway of its utilization LIKE .....

--- Content provided by FirstRanker.com ---


? Ketosis, cholesterol synthesis, and fatty acid synthesis.
? Excess ketone bodies produced by Liver , continued if not

treated leads to ketoacidosis.

--- Content provided by FirstRanker.com ---

LONG STANDING METABOLIC EFFECT.

AGEs( advanced glycation end products).

High glucose in tissue

--- Content provided by FirstRanker.com ---


leads to non enzymatic attachment of glucose and

its metabolites to several protein like Hb, albumin,

--- Content provided by FirstRanker.com ---

collagen etc. This process is called glycation.

Ultimately leads to the formation of advanced

glycation end product which causes cellular

--- Content provided by FirstRanker.com ---


dysfunction.one such glycated protein is HbA1c.



--- Content provided by FirstRanker.com ---


CATARACT--(polyol-pathway)--High glucose leads

to sorbitol accumulation causing cellular

--- Content provided by FirstRanker.com ---

dysfunction. Cataract is believed to be a result of

osmotic effect of sorbitol accumulation.


--- Content provided by FirstRanker.com ---

Clinical features of Diabetes Mellitus.

? Polyurea.

? Polydipsia.

--- Content provided by FirstRanker.com ---



.Polyphagia.

? Fatigue.

--- Content provided by FirstRanker.com ---


? Weight Loss.



--- Content provided by FirstRanker.com ---



DIAGNOSIS OF DIABETES

MELLITUS.

--- Content provided by FirstRanker.com ---


WHO guidelines

? FBG? 126mg%.

--- Content provided by FirstRanker.com ---

? PP-- 200%.

? RBG--> 200 mg% with symptomps of diabetes mellitus.

? Glycated Hb( HbA1c) > 6.5gm%.

--- Content provided by FirstRanker.com ---

DIFFERENT TYPES OF BLOOD GLUCOSE TESTS.

FBS

RBG

--- Content provided by FirstRanker.com ---


2-HourPP

HbA1c

--- Content provided by FirstRanker.com ---

OGTT
Diabetic profile.

Blood glucose.

--- Content provided by FirstRanker.com ---

4 types :FBS, PPBS, RBS, OGGT.

Urine Analysis.

Urine sugar/urine protein/urine microalbum/ketones.

--- Content provided by FirstRanker.com ---


HbA1C

Insulin

--- Content provided by FirstRanker.com ---

C-peptide
FASTING BLOOD SUGAR.

? Normal level
? 70---110mg/dl.

--- Content provided by FirstRanker.com ---


110mg/dl

126mg/dl

--- Content provided by FirstRanker.com ---

Diabetic
NORMAL BLOOD GLUCOSE

LEVEL

--- Content provided by FirstRanker.com ---

? FBG---70---110mg%.

? PP-----Less than 140 mg% after 75 mg

glucose load.

--- Content provided by FirstRanker.com ---


? HbA1c ?below 6.5 gm%.
INSULIN RESISTANCE

SYNDROME.

--- Content provided by FirstRanker.com ---


? Also known as Metabolic syndrome or the syndrome X,

characterised by the following....

--- Content provided by FirstRanker.com ---

? Insulin resistance indicated by blood glucose inspite

of insulin level in blood.

? Hypertension.

--- Content provided by FirstRanker.com ---

? Dyslipidemia((LDL + TG).
? Central obesity.
? Accelerated cardiovascular disease.
? Insulin resistance syndrome is due to post- receptor

--- Content provided by FirstRanker.com ---

signaling defect in target tissues, e.g. Skeletal muscle.
COMPLICATION OF DIABETES

MELLITUS.

--- Content provided by FirstRanker.com ---

Complication of DM.

Chronic

Acute

--- Content provided by FirstRanker.com ---


Diabetic ketoacidosis.and

Microvas--

--- Content provided by FirstRanker.com ---

Macro--MI, STROKE

Hyperglycemic non ketotic

retinopathy,neuropathy,neph.

--- Content provided by FirstRanker.com ---


hyperosmor.
? Alteration in blood sugar: hyperglycemia and

Hypoglycemia.

--- Content provided by FirstRanker.com ---


? Macrovascular( Larege blood vessels)
? Atherosclerosis involving :-
? coronary, cerebral and

--- Content provided by FirstRanker.com ---

peripheral arteries.

? Microvascular( small blood vessels):-
? affects basement membrane

--- Content provided by FirstRanker.com ---

of small blood vessels and capillaries involving

Eyes and Kidneys.

HYPERGLYCEMIA.

--- Content provided by FirstRanker.com ---


? High blood sugar
? DKA
? HHKs
? Dawn phenomenon-

--- Content provided by FirstRanker.com ---

? Rise in blood sugar between 4 a.m. And 8 a.m.
? Not associated with hypoglycemia.
? SOMOGYI phenomenon----
? Combination of hypoglycemia during night with a

--- Content provided by FirstRanker.com ---

rebound morning hyperglycemia that may lead to

insulin resistance for 12 to 48 hours.
ACUTE COMPLICATION

--- Content provided by FirstRanker.com ---

? Hypoglycemia
? Diabetic ketoacidosis.
? Hyperglycemic hyperosmotic non ketotic coma.
? HYPOGLYCEMIA:--
? Serum glucose < 55 mg/100ml.

--- Content provided by FirstRanker.com ---

? Brain damage develops when the brain is

deprived of needed glucose after a dramatic drop

in blood sugar.

--- Content provided by FirstRanker.com ---

HYPOGLYCEMIA

SIGN AND SYMPTOMPS.

? MILD:-

--- Content provided by FirstRanker.com ---

?
? Palpitation, pallor , tremors, anxiety
? Parasthesia,
? MODERATE:-
? confusion, cold extremities, blurred

--- Content provided by FirstRanker.com ---


vision.

? SEVERE:-
? Seizure, Loss of consciousness,can

--- Content provided by FirstRanker.com ---


result in death.
Otherscomplication.

? Cataract.

--- Content provided by FirstRanker.com ---

? Glucoma.
? Infection-Foot ulcer, osteomyelitis.
? Skin infection--candiasis and other fungal

infection.

--- Content provided by FirstRanker.com ---

DIABETIC KETOACIDOSIS.

? Diabetic ketoacidosis is the most dreaded acute

complication resulting from uncontrolled

--- Content provided by FirstRanker.com ---


diabetes mellitus, characterised by

? Severe hyperglycemia-Blood glucose is very high,

--- Content provided by FirstRanker.com ---

commonly 400- 500 mg %.

? Dehydration due to polyurea.
? Ketosis--due to increased production of ketone

--- Content provided by FirstRanker.com ---

bodies as a result of hyperglycemia.

? Ketone body test is positive in urine.
DKA: 4 main clinical features.

--- Content provided by FirstRanker.com ---

? 1.Hyperglycemia
? 2.Dehydration
? 3.Eectrolyte loss.
? 4.Metabolic Acidosis.
PATHOPHYSIOLOGY DKA.

--- Content provided by FirstRanker.com ---


NO insulin

Glucose stays in

--- Content provided by FirstRanker.com ---

Muscle not geting

Fat metabolism

blood

--- Content provided by FirstRanker.com ---


energy

Increased ketone in

--- Content provided by FirstRanker.com ---

Hyperglycemia

blood

Osmotic diuresis

--- Content provided by FirstRanker.com ---


Metabolic Acidosis

Electrolyte

--- Content provided by FirstRanker.com ---

polyurea

imbalance

Serum pH

--- Content provided by FirstRanker.com ---


polydipsia

Respiratory rate.

--- Content provided by FirstRanker.com ---

Dehydration
? Acidosis with increased anion gap---
? PH 6.8--7.3 and

anion gap of >15mEq/L.

--- Content provided by FirstRanker.com ---


? Hyperventilaton with fruity odour of breath---
? Acidisis stimulates respiration leading to

hyprventilation. Excretion of acetone (ketone

--- Content provided by FirstRanker.com ---


bodies) in the breath is responsible for fruity

odour in breath.
? Other symptomps include--

--- Content provided by FirstRanker.com ---

? Nausea
? vomiting
? pain abdomen
? letharginess
? Depression......etc.

--- Content provided by FirstRanker.com ---

? Hyperkalemia and hypontremia.
? It is acute medical emergency.
? Patient is admitted and treated with

intravenous insulin, fluids and electrolytes to

--- Content provided by FirstRanker.com ---


correct dehydration and electrolyte imbalance.
Glycated Hemoglobin.

? Glycated Hb(HbA1c)---Is formed by non-

--- Content provided by FirstRanker.com ---


enzymatic addition of N- terminal Valine of Hb

Beta chain due to persistent hyperglycemia.

--- Content provided by FirstRanker.com ---

? Its level in blood gives an estimate of blood

glucose over the preceding 6-8 weeks.