Download MBBS Case Studies Related to Jaundice and Liver Disorders Lecture PPT

Download MBBS (Bachelor of Medicine and Bachelor of Surgery) Latest Case Studies Related to Jaundice and Liver Disorders Lecture PPT


Resmi, 18 years staying in a college hostel, brought in the

outpatient clinic of medical college complaining of fever, head

ache, nausea and yellowish discoloration of sclera O/E: febrile,

Jaundice + liver palpable

Laboratory data:
Total bilirubin- 6 mg% (0.3-1.2 mg/dl)
Conjugated bilirubin- 2.6 mg% (0.1-0.4 mg/dl)
ALP- 200 IU/L (40-125 IU/L)
ALT- 80 IU/L (10-35 IU/L)
AST- 70 IU/L ( 8-30 IU/L)
Urinary Bile salts- +
Urinary Bile Pigment- +
Urinary Urobilinogen- Trace
What kind of illness, the girl is suffering from?
Evaluate the clinical condition by the laboratory data

provided?

The girl is suffering from hepatic jaundice.
The clinical features fever, headache and nausea are

suggestive of an infection and the finding of liver

enlargement with yellowish discoloration is suggestive

of hepatic jaundice
Laboratory data confirms the hepatic origin of

jaundice

Serum bilirubin levels
Elevated total bilirubin levels suggest jaundice
Hepatocyte dysfunction affecting glucoronyl

transferase activity caused elevation of unconjugated

bilirubin (6-2.6=3.4 mg%)

The delayed clearance of CB due to blockage of biliary

micro channels by inflammation leading to slight hike

in its level
Serum enzymes
Rise in transaminase shows injury to hepatocyte and its release

from the cytoplasm of hepatocytes due to infection.

Slight elevation of ALP points towards the release of membrane

bound ALP resulting from pressure effect produced by

inflammatory swelling of biliary lining cells caused by

infection.

Urinary finding of positive bile salts and bile pigments again

indicate the patient is in the obstructive phase of hepatic

jaundice i.e. infection causing inflammation of lining cells of

biliary canaliculi which results in regurgitation of biliary content

in to blood stream.

When blood levels of these compounds crosses the renal thresh

hold for that substance, it gets excreted in urine- thus CB and

bile salts are excreted in urine
Urobilinogen in trace amount suggests that there is no severe

obstruction as in biliary stone, strictures etc which cause

complete obstruction of biliary flow in to intestine.

How to differentiate hepatic jaundice from obstructive

jaundice due to stones,tumors or other obstruction in biliary

tract?

Serum bilirubin values
In obstructive jaundice the level of CB will be much higher than

the hepatic jaundice and UCB values remain within normal

limits

Enzymes
Transaminase values generally remain within normal range but

ALP values will be very high in obstructive jaundice
Urinary findings
Bile salts + ve and CB + ve and urobilinogen will be

absent.

Due to biliary obstruction CB can not reach the

intestine in obstructive jaundice and hence

urobilinogen can not be formed as in normal situation.

Urine will be giving negative response to Ehrlich's test

and the patient will complain of passing clay coloured

stools due to absence of stercobilinogen in feces.
Kurinji, 45 years old woman, a tribal hailing from waynaud district with severe

tiredness and severe pain all over the body O/E: Pallor+, Jaundice +,

Hepatosplenomegaly.

Based on clinical and laboratory data what is your provisional diagnosis?
What other tests do you require to confirm diagnosis?

Laboratory data
Hb- 7 g%
Sickling test- +ve
Total bilirubin- 10 mg%
CB- 0.6 mg%
UB- 9.4%
ALP- 45 IU/L
ALT- 14 IU/L
AST- 20 IU/L
URINE

Bile salts- Negative
Bile pigment-Negative
Urobilinogen- Strongly positive

The women is suffering from hemolytic jaundice probably due

to sickle cell disease.

Total bilirubin and UCB are high- suggesting increase in bilirubin

not due to any obstruction in the biliary passages.

Serum enzyme studies show normal activities indicating that

hepatocytes are not involved in disease process thereby

excluding hepatic jaundice.

Absence of bile salts and bile pigment in urine show that

jaundice is not due to any obstruction.
Increased urobilinogen is due to increase rate of RBC
break down producing maximum amount of

conjugated bilirubin getting secreted into intestine

and converted to urobilinogen in increasing amounts

which is then absorbed from intestine in to blood and

excreted in urine in excess amount.
The positive sickling test, tribal origin of the woman

and the kind of pain is suggestive of sickling crisis and

strongly suggestive of sickle cell disease.
It is to be confirmed by Hb electrophoresis
Meenakshi,58 year old woman c/o pain in the upper

right side of the abdomen, fever with chills, pruritus ,

passing dark color urine and clay colored stools. O/E:

Jaundice +, scratch marks on the skin +, fever+.

From the following laboratory data explain what

would be provisional diagnosis?

Serum TB- 12 mg%
CB- 10 mg%
ALP- 300 IU/L
ALT- 30 IU/L
AST- 18 IU/L
Urine
Bile salts- +ve
Bile pigment- +ve
Urobilinogen- Negative

The lady is suffering from obstructive jaundice

(cholestasis)

Total bilirubin and conjugated bilirubin is high ?

suggesting of obstruction of biliary passages leading to

cholestasis.

Serum enzyme studies shows high ALP indicating

obstructive type of jaundice and normal transaminases

giving an idea hepatocytes are unaffected by the disease

process.
Urine- Test for Bile salts (Hay's test) +ve- supporting

the diagnosis of obstructive jaundice.

Obstruction of biliary passages causing stasis of its

contents leading to regurgitation of its constituents

into blood and thereby elevating the concentration of

CB and bile salts in to blood.

Bile salts has a tendency to get deposited in the skin

causing intense pruritus and CB and Bile salts will be

excreted in urine

This post was last modified on 30 November 2021