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Download MBBS Trafficking of Protein II Lecture PPT

Download MBBS (Bachelor of Medicine and Bachelor of Surgery) Latest Trafficking of Protein II Lecture PPT

This post was last modified on 30 November 2021


Transport into the nucleus



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? Proteins similar to importins, referred to as exportins, are

involved in the export of

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many macromolecules (various

proteins, tRNA molecules, ribosomal subunits and
certain mRNA molecules) from the nucleus

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? Cargo molecules for export carry nuclear export signals

(NESs).

? Ran proteins are involved in this process also

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? The family of importins and exportins are referred to as

karyopherins

? Another system is involved in the translocation of the

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majority of mRNA molecules.

? These are exported from the nucleus to the cytoplasm as

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ribonucleoprotein (RNP) complexes attached to a protein
named mRNP exporter


Peroxisomes

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Transport into peroxisomes
Transport into peroxisomes

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? Peroxins - peroxisome transport receptors
? Bind to proteins with PTS1 and dock to the

translocation channel

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? The complex is transported through the membrane
? Protein is released
? Peroxin is recycled


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Zellweger syndrome

? Usually caused by mutations in genes encoding certain

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proteins--the PEX family of genes, also called peroxins

--involved in various steps of peroxisome biogenesis

? Number of peroxisomes can vary from being almost

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normal to being virtually absent in some patients

? Apparent at birth and is characterized by profound

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neurologic impairment, victims often dying within a year

? Biochemical findings include an accumulation of very-

long-chain fatty acids, abnormalities of the synthesis of

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bile acids, and a marked reduction of plasmalogens

? Two closely related conditions are neonatal

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adrenoleukodystrophy and infantile Refsum disease.