Physical Pharmaceutics - I : BP 403 T
Time : Three Hours Max. Marks : 75
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Notes: 1. Answer all questions.
2. Assume suitable data wherever necessary.
3. Illustrate your answer necessary with the help of neat sketches.
- MCQ's. 20
- - dispersions are unstable in the presence of even small concentration of electrolytes.
- a) Lyophilic
- b) Hydrophilic
- c) Amphiphilic
- d) Lyophobic
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- The size of dispersed phase particles of colloidal dispersions is ----------.
- a) Less than 1 nm
- b) Greater than 5 um
- c) 1nm to 0.5um
- d) Greater than 0.5 pm
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- The protective property of hydrophilic colloids is expressed in terms of -----------.
- a) Gold number
- b) Lyotropic series
- c) HLB value
- d) All of the above
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- The ability of amphiphilic colloids to increase the solubility of normally insoluble materials in solution is known as ---------- :
- a) Peptization
- b) Sensitization
- c) Protection
- d) Micellar solubilization
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- Ostwald's viscometer is a ---------- viscometer.
- a) Capillary
- b) Falling sphere
- c) Cone and plate
- d) Cup and bob
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- Bingham bodies are ---------- in nature.
- a) Shear thickening
- b) Dilatant
- c) Shear thinning
- d) Newtonian
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- The ---------- is a dimensionless quantity.
- a) Stress
- b) Rate of shear
- c) Strain
- d) Elastic modulus
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- Deflocculated suspensions containing high concentration of small particles exhibit ----- flow.
- a) Newtonian
- b) Plastic
- c) Pseudo-Plastic
- d) Dilatant
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- The diameter of a sphere having same sedimentation rate as asymmetrical particle under question is known as -------- diameter.
- a) Surface
- b) Volume
- c) Projected
- d) Stoke's
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- The true density of particles can be measured by --------- method.
- a) Mercury displacement
- b) Liquid displacement
- c) Helium penetration
- d) All of the above
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- The ratio of void volume to bulk volume is known as ----------.
- a) Porosity
- b) Compressibility
- c) Bulkiness
- d) Bulk density
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- The theoretical porosity of powder containing uniform spheres is -------- in the closest pack.
- a) 20%
- b) 74%
- c) 48%
- d) 52%
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- The velocity of suspended particles is inversely proportional to ----- :
- a) Density of dispersed phase
- b) Density of dispersion medium
- c) Radius of dispersed phase particles
- d) Viscosity of dispersion medium
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- The velocity of sedimentation of dispersed particles is ---------- in flocculated suspensions than deflocculated.
- a) Slower
- b) Faster
- c) Same
- d) None of a,b,c
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- Surfactants form -------- film at o/w interface in an emulsion.
- a) Protective
- b) Monomolecular
- c) Multimolecular
- d) Particulate
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- ---------- is a reversible incompatibility observed in emulsions.
- a) Breaking
- b) Phase inversion
- c) Creaming
- d) Coalescence
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- The rate of ---------- order reactions is proportional to the concentration.
- a) Zero
- b) Pseudo
- c) First
- d) Second
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- The unit for rate constant of a -------- order reaction is second-1.
- a) Zero
- b) Pseudo
- c) First
- d) Second
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- Classic-collision theory explains the effect of ---------- on rates of reactions.
- a) pH
- b) Temperature
- c) Catalysis
- d) Humidity
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- The half-life in a zero-order reaction is described by ---------- ;
- a) t1/2 = 2’;"0
- b) t1/2 = %
- c) %:i 9
- d) A;K'OA
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- - dispersions are unstable in the presence of even small concentration of electrolytes.
- Long answer questions any two. 20
- a) Classify the flow properties of liquids with relevant equations and rheograms. Add a note on Thixotropy.
- b) Describe the derived properties of powders in details.
- c) Define rate, order & molecularity of a reaction & derive equation for first order reaction.
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- Short answer Questions any seven. 35
- a) Write a note on expiration dating of pharmaceutical dosage forms.
- b) Describe any two methods of determination of particle size.
- c) Write in brief about equivalent spherical diameters.
- d) Give an account of optical properties of colloids.
- e) Write a note on protective colloid action.
- f) Discuss Bulges & spurs with relevant examples.
- g) Enlist the instabilities in emulsions and discuss any two in details.
- h) Write a note on sedimentation parameters.
- i) Discuss Arrhenius theory in brief.
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