Download RGUHS (Rajiv Gandhi University of Health Sciences) MBBS (Bachelor of Medicine and Bachelor of Surgery) 2021 June 1025 Biochemistry Paper II Rs 4 Previous Question Paper
MBBS Phase ? I (CBME) Degree Examination - 24-Jun-2021
Time: Three Hours
Max. Marks: 100 Marks
BIOCHEMISTRY ? PAPER II (RS-4)
Q.P. CODE: 1025
(QP contains three pages)
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAYS
2 x 10 = 20 Marks
1. 1. A 6 year old child was brought to the OPD with complaints of Mental retardation, delayed
developmental milestones, hyperactive and seizures. The child had light coloured hair,
skin and unpleasant mousy body odour. Serum Phenylalanine was 35mg/dl (Normal
1-2mg/dl). Ferric chloride test showed transient blue green colour in urine.
a. Suggest the probable diagnosis?
b. Mention the enzyme defect and write the reaction catalysed by their enzyme
c. Write the biochemical basis for the following clinical findings:
i.
Neurological manifestations
ii.
Light colouredhair and skin
iii.
Mousy body odour
d. Describe the steps for synthesis of any two biological important compounds derived
from tyrosine. (1+2+3+4)
2. 1. Explain in detail the reactions of Heme synthesis? Name the regulatory enzyme of this
pathway. How is it regulated? (6+1+3)
SHORT ESSAYS
8 x 5 = 40 Marks
3. 2. Classify amino acids based on their nutritional significance giving examples. What are non
protein amino acids? Give one example. (3+1+1)
3.
4. 4. Mention any four anticancer drugs and write their mechanism of action. (1+4)
5.
5. 6. A 40 year old male came with the complaints of difficulty in breathing, shortness of breath
and tightness of chest. History revealed that he is a chronic smoker for the past
15years.Chest X-ray and CT scan showed changes suggestive of emphysema.
a. Deficiency of which plasma protein causes this condition?
b. Explain the biochemical basis of emphysema in smokers?
c. Name any two serine proteases? (1+2+2)
7.
6.
Explain the tests done to assess the renal tubular functions? What is urine osmolality?
Write its reference range? (3+1+1)
7.
Name the RNA which carries amino acids to the site of protein biosynthesis. With
illustration explain the structure. (1+4)
8.
A four year old child was brought to the hospital with the following complaints
developmental failure, aggressive behavior, joint pain, compulsive urge to bite his lips and
fingers. Mother revealed a family history of similar illness among family members.
a. Suggest the probable diagnosis.
b. Name an appropriate biochemical parameter to diagnose this condition and state its
reference range in males and females
c. Name the enzyme deficiency and the reaction catalysed by the enzyme (1+2+2)
9.
Explain Lac operon concept with a diagrammatic representation.
10. Classify antioxidants giving two examples for each class.
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Rajiv Gandhi University of Health Sciences, Karnataka
SHORT ANSWERS
10 x 3 = 30 Marks
11. Telomerases are involved in aging process. Justify and give its clinical significance. (1+2)
12. What is Southern blot technique? Write two applications of this technique. (1+2)
13. Mention any three salient features of DNA replication. (3)
14. What is detoxification? Give two examples of conjugation phase reactions? (1+2)
15. What are DNA probes? Write their applications. (1+2)
16. What are oncosuppressor genes? Name any two with their mechanism of action. (1+2)
17. Give reason for the following:
a. Restriction enzymes are termed as molecular scissors
b. Changing color of the bruise
c. Hemolytic jaundice is also called a acholuric jaundice (1+1+1)
18. Illustrate the sources of carbon and nitrogen atoms in Purine ring. (3)
19. Write the biochemical findings in the serum and urine in obstructive jaundice. (3)
20. Give reason for the following:
a. Pellagra like symptoms are seen in Hartnups disease
b. Glycine does not exhibit optical activity
c. Proline is an - helix breaker (1+1+1)
Multiple Choice Questions
10 x 1 = 10 Marks
21 i) The protein part present in nucleoprotein is
a. Globin
b. Opsin
c. Histones
d. Apoferritin
21 ii) The enzyme defect in Acute intermittent porphyria
a. PBG- deaminase
b. UPG-cosynthase
c. Ferrochelatase
d. UPG-decarboxylase
21 iii) The following compounds are biosynthesized by Glycine EXCEPT
a. Creatinine
b. Heme
c. Melatonin
d. Purine nucleotide
21 iv) 5'-Nucleotidase is more specific for
a. Myocardial Infarction
b. Prostate cancer
c. Obstructive liver disease
d. Wilson's disease
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Rajiv Gandhi University of Health Sciences, Karnataka
21 v) Appearance Black colour urine is seen in
a. Porphyria
b. Alkaptonuria
c. Jaundice
d. Urinary tract infection
22 i)
Which of the following has not been treated by gene therapy?
a. Hemophilia
b. Severe combined immunodeficiency
c. Cystic fibrosis
d. Glucose ? 6- phosphatase deficiency
22 ii) Helicase enzyme in DNA replication -
a. Unwinds the DNA
b. releases the supercoils
c. breaks the strands
d. seals the strands
22 iii) Western blot technique is used for the
a. Detection of specific DNA segment
b. Detection of specific gene expression
c. Identification of a specific protein
d. Location of a gene on a specific chromosome
22 iv) Urine preservatives are used for all the following purposes EXCEPT
a. Reduce bacterial action
b. Minimize chemical decomposition
c. Increase pH
d. Decrease atmospheric oxidation of unstable compounds
22 v) Serum Alpha Fetoprotein level is increased in
a. Multiple Myeloma
b. Choriocarcinoma
c. Hepatoma
d. Lung cancer
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This post was last modified on 02 December 2024