Download OU Pharm D Question Paper 1st Year 2016 6115 Pharmaceutical Organic Chemistry

Download OU (Osmania University) Pharm D (Doctor of Pharmacy) 1st Year 2016 6115 Pharmaceutical Organic Chemistry Previous Question Paper

OU - 1705 OU - 1705
Code No. 6115
FACULTY
Pharm D (6 ? YDC) I ? Year (Main / Backlog) Examination, August 2016
Subject: Pharmaceutical Organic Chemistry
Time: 3 Hours Ma x.Marks: 70
Note: Answer all questions from Part ? A. Any Five questions from Part ? B.
PART ? A (10x2 = 20 Marks)
1 Write the IUPAC name of the following:
CH
3
|
a) CH
3
? C = CH ? CH = CH
2
O O
|| ||
b) CH
3
? C ? CH
2
? C ? CH
3
2 Give the step involved in the conversion of aniline into para-nitro aniline.
3 Give the structure formula of
a) Methyl-1-penten-4-yne
b) 5-Hydroxy-3-hexenal
4 Comment on ethanol and dimethyl ether are isomer, but differ in the boiling point.
5 Briefly explain Bayer?s strain theory.
6 Write the different between SN
1
and SN
2
.
7 Explain Saytzeff rule.
8 Classify each of the following nucleophil or electrophil
1) NH
2
2)
+
30
H 3) CN
-
4) Cl
2
9 Predict the product
i) CH
3
? CH = CH
2
+ HBr ????????
Peroxide
?
ii) CH
3
? CH = CH
2
+ HBr ??????????
No-Peroxide
10 Explain Cannizzaro reaction.
PART ? B (5x10 = 50 Marks)
11 Explain the nucleophillic substitution reaction with Mechanism. 10
12 Explain with mechanism: 10
i) Aldol-condensation
ii) Sadmeyer?s reaction
?2
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OU - 1705 OU - 1705
Code No. 6115
FACULTY
Pharm D (6 ? YDC) I ? Year (Main / Backlog) Examination, August 2016
Subject: Pharmaceutical Organic Chemistry
Time: 3 Hours Ma x.Marks: 70
Note: Answer all questions from Part ? A. Any Five questions from Part ? B.
PART ? A (10x2 = 20 Marks)
1 Write the IUPAC name of the following:
CH
3
|
a) CH
3
? C = CH ? CH = CH
2
O O
|| ||
b) CH
3
? C ? CH
2
? C ? CH
3
2 Give the step involved in the conversion of aniline into para-nitro aniline.
3 Give the structure formula of
a) Methyl-1-penten-4-yne
b) 5-Hydroxy-3-hexenal
4 Comment on ethanol and dimethyl ether are isomer, but differ in the boiling point.
5 Briefly explain Bayer?s strain theory.
6 Write the different between SN
1
and SN
2
.
7 Explain Saytzeff rule.
8 Classify each of the following nucleophil or electrophil
1) NH
2
2)
+
30
H 3) CN
-
4) Cl
2
9 Predict the product
i) CH
3
? CH = CH
2
+ HBr ????????
Peroxide
?
ii) CH
3
? CH = CH
2
+ HBr ??????????
No-Peroxide
10 Explain Cannizzaro reaction.
PART ? B (5x10 = 50 Marks)
11 Explain the nucleophillic substitution reaction with Mechanism. 10
12 Explain with mechanism: 10
i) Aldol-condensation
ii) Sadmeyer?s reaction
?2
OU - 1705 OU - 1705
Code No. 6115
-2-
13 Define rearrangement reaction. Explain mechanism of following reaction. 10
i) Fries rearrangement reaction
ii) Hoffman rearrangement reaction.
14 Explain the mechanism of electrophillic substitution reaction taking a suitable example. 10
15 Write the short notes on: 10
i) Resonance concept
ii) Acid-Base theory.
16 Explain mechanism involved in following reaction: 10
i) Kolbe reaction
ii) Michael addition
17 a) Explain Friedel-Craft Alkylation reaction and write its drawback.
b) Write a note on activating and deactivating O, P and M directing group.
18 a) Explain diazo-coupling reaction with mechanism.
b) Write a note on elimination reaction.
****
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