Download OU Pharm D Question Paper 3rd Sem 2017 4267 Medicinal Chemistry

Download OU (Osmania University) Pharm D (Doctor of Pharmacy) 3rd Year (3rd Semester) 2017 4267 Medicinal Chemistry Previous Question Paper

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Code No. 4267
FACULTY OF PHARMACY
Pharm. D (6 YDC) III-Year (Main) Examination, July 2017
Subject : Medicinal Chemistry
Time : 3 Hrs Max. Marks: 70
Note: Answer all questions from Part - A and answer any five questions from Part-B.
PART ? A (10 x 2 = 20 Marks)
1 What are varis parameter used in QSAR?
2 Give two structure of Loop diuretics.
3 What is application of combinational chemistry?
4 What are diagnostic Agents? Give one example with an application?
5 What is the action of anti ineffective drugs?
6 Some drug containing an ester grp are inactive invitro but once the drug absorbed invivo.
what term is used for such drug (i) post drug (ii) predrug (iii) Metabolite (iv) pro-drug
7 Define antithrombolytic.
8 Give popular brand name of following drugs.
(i) Cefadroxil (ii) Tinadazole (iii) ofloxacin (iv) melformin
9 Sketch the structure and medicinal use of chloramphenicol.
10 Write the mechanism of action of anti-angina agent.
PART ? B (5 x 10 = 50 Marks)
11 (a) Write a note Antiscables and antipediculars agent.
(b) Write the SAR of tetracycline.
12 Write the synthesis, mechanism of action of following drug (i) cefadroxil (ii) Isomazy
(iii) ampicillin (iv) metronidazole
13 (a) Classify sulphonamides. Give one example with structure for each class.
(b) tline the synthesis of (i) Enalapris (ii) Mechlor ethamin
14 (a) Write the SAR of angio-tension - II antagonist.
(b) Write a note on antithyroid agents.
15 (a) Give a brief accnt on steroidal hormones.
(b) Write the synthesis of any two drugs belonging to class anti-malarial.
16 (a) Classify diuretics with examples. Write the synthesis of acetozolmide.
(b) Write a note on macrocide agent.
17 (a) Classify antihyper lidemic agents and write the synthesis any one of them.
(b) tline the synthesis of Tolbutamide and metformin.
18 (a) Write a note on local infective agents.
(b) Classify the pro-drug and enlist the ideal property.
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