Download GTU B.Tech 2020 Winter 5th Sem 3153601 Pharamceutical Chemistry Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Tech/BE (Bachelor of Technology/ Bachelor of Engineering) 2020 Winter 5th Sem 3153601 Pharamceutical Chemistry Previous Question Paper

Seat No.: ________
Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE- SEMESTER?V (NEW) EXAMINATION ? WINTER 2020
Subject Code:3153601 Date:01/02/2021
Subject Name:Pharamceutical Chemistry
Time:10:30 AM TO 12:30 PM Total Marks: 56
Instructions:
1. Attempt any FOUR questions out of EIGHT questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.


MARKS
Q.1 (a) Define (1). Hyperglycemia, (2). Type-1 diabetes, (3). Type-2
03
diabetes

(b) Write notes on (1). Oral Iron therapy, (2). Parenteral Iron therapy
04

(c) Write the chemical degradation of Penicillin with structures
07
Q.2 (a) What are hormones? Write the classification of hormones.
03

(b) Discuss any four guidelines for choosing a disconnection in
04
Retrosynthesis. Give suitable examples wherever required

(c) Write the MOA, SAR of Sulphonyl urea class of antidiabetic drug.
07
Give one example and write the synthesis of it.
Q.3 (a) Write the general structure of (1).Penicillin,(2) Cephalosporin
03

(b) Write the disconnection of Cis(Z)-Jasmone (only disconnection).
04
Write the steps to get the correct regiochemistry & cis
stereochemistry(structure given)
cis(Z) Jasmone

(c) What are (1). Synthons, (2). Retrosynthesis ? By disconnection
07
approach, suggest a scheme for synthesis of antituberculosis drug-
para amino salicylic acid




Q.4 (a) Write the MOA of Penicillin antibiotics
03

(b) By disconnection method write the synthesis of (1R, 2S)-(-)-
04
Ephedrine. Write the resolution procedure to get (1R, 2S)-(-)-
Ephedrine(structure given)
(1R,2S)(-)-Ephedrine

(c) By disconnection method, write the synthesis of (1). Propranolol,
07
(2). Bropirimine. (structures given)
(1).Propranolol

(2). Bropirimine
Q.5 (a) Write the structure of Cholestane template and show how it is 03
numbered

(b) Write the synthesis of Metronidazole- a drug molecule containing
04
imidazole heterocycle. (structure given)
1

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(c) Write the biosynthesis of sex hormones from Cholesterol
07




Q.6 (a) Write the structure (1). Pregn-4-ene-3,20-dione, (2). 17-beta
03
hydroxy- androst-4-ene-3-one

(b) Write the synthesis of sedative Glutethimide- a drug molecule
04
containing piperidine heterocycle derivative. (structure given)


(c) Write the SAR of Oestrogens
07
Q.7 (a) Define Hypothyroidism. Write one example with structure of
03
thyroid drug. Write its MOA

(b) Describe the roles of the three hormones in Calcium homeostasis
04

(c) By disconnection approach, write the synthesis of NSAID-
07
Ibuprofen. (structure given)



Q.8 (a) Define antithyroid drugs. Give two examples with structure.
03
(b) What are hormonal contraceptives? Write a note on oral
04
contraceptives
(c) By disconnection approach, write the synthesis of antidepressant-
07
Venlafaxine. (structure given)
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