Download GTU (Gujarat Technological University Ahmedabad) B.Tech/BE (Bachelor of Technology/ Bachelor of Engineering) 2020 Winter 7th Sem 2173602 Process Technology Of Drugs And Intermediates Previous Question Paper
Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE- SEMESTER?VII (NEW) EXAMINATION ? WINTER 2020
Subject Code:2173602 Date:19/01/2021
Subject Name:Process Technology of Drugs & Intermediates
Time:10:30 AM TO 12:30 PM Total Marks: 56
Instructions:
1. Attempt any FOUR questions out of EIGHT questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a) Define: (1). Validation, (2). Qualification, (3). GMP
03
(b) Define chiral auxiliary. Describe the use of chiral auxiliary with a
04
schematic diagram. Write one example of the use of chiral
auxiliary.
(c) List out the techniques in identifying exothermicity & gas
07
generation. Briefly explain them. Illustrate use of calorimetry in
designing safe scale up process with two examples.
Q.2 (a) What are super critical solvents? Give an example. What are the
03
advantages & disadvantages of super critical solvents?
(b) Describe the working of simulated bed chromatography with
04
diagram. What are the advantages & disadvantages?
(c) What are the classifications of Enzymes? Write in detail about
07
Lipases & Esterases with suitable examples of reactions catalyzed
by them.
Q.3 (a) Write a note on "sources of enzyme"
03
(b) Discuss Ultra filtration & Microfiltration
04
(c) Explain the different types of Process validations. What are the
07
types of validation documents?
Q.4 (a) Define process safety. Write a note on the types of hazards
03
(b) Explain Marckwald principle & Reciprocal resolutions. Illustrate
04
with example.
(c) Describe the need, different types of "Qualifications" in
07
Pharmaceutical industries. Explain qualification protocol.
Q.5 (a) Define adsorption. Write the theory & factors affecting adsorption.
03
(b) Describe process safety failures and the consequences.
04
(c) Write briefly the factors to be considered while selecting filtration
07
equipment. Describe any two filtration equipments with neat
diagrams.
Q.6 (a) What are the selection criteria for resolving agents. Give one
03
example of the use of resolving agent.
(b) Describe residual solvents? Write a note on the classification of
04
solvents by risk assessment.
(c) Discuss in detail the optimization of process. Illustrate with suitable
07
examples.
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Q.7 (a) Write a brief account on "Regulation of Enzyme activity"
03
(b) Define "reagent"? Explain the properties to be considered while
04
selecting a reagent.
(c) List out the factors to be considered while choosing solvent and
07
explain them.
Q.8 (a) Write a note on (1) Ion exchange chromatography, (2). Gel
03
filtration chromatography
(b) Write a note on Phase transfer catalyst. What are the factors to be
04
considered while choosing a Phase Transfer Catalyst (PTC) & how
selectivity in PTC can be achieved?
(c) Describe two methods of resolution of racemates by direct
07
crystallization with suitable examples.
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This post was last modified on 04 March 2021