Download GTU B.Pharma 2020 Winter 5th Sem 2250004 Pharmaceutical Chemistry Vii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Winter 5th Sem 2250004 Pharmaceutical Chemistry Vii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. - SEMESTER? V? EXAMINATION ? WINTER -2020
Subject Code: 2250004
Date: 11/01/2021
Subject Name: Pharmaceutical Chemistry - VII
Time: 10:30AM TO 12:30PM
Total Marks: 54
Instructions:


1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.
Q.1 (a) Define and classify diagnostic agents. Explain in detail positive contrast media.
06

(b) Write a note on neuromuscular blocking agents.
05

(c) Discuss in detail SAR of H2 receptor blockers.
05



Q.2 (a) Give the IUPAC name and synthesis of following compound:
06
a) Propranolol b) Diatriazoic acid

(b) What is Medicinal Chemistry? Describe importance of Medicinal chemistry in 05
drug discovery.

(c) Discuss in detail drugs for irritable bowel syndrome.
05



Q.3 (a) Enlist various physicochemical parameters. How partition coefficient and 06
ionization affects biological activity of drug.

(b) Explain in detail SAR of muscarinic antagonists.
05

(c) Give the structure and IUPAC name of following compounds:
05
a) Atenolol b) Dicyclomine HCl c) Chlorpheniramine d) Promethazine
e) Salbutamol



Q.4 (a) Define asthma. Classify the drugs used in treatment of asthma with suitable 06
example. Discuss bronchodilators in detail.

(b) Give the synthesis of a) Adrenaline b) Promethazine
05

(c) Write a Short note on Mucolytic agents.
05



Q.5 (a) Explain in detail Cyclooxygenase pathway.
06

(b) Explain Laxatives. Classify them with suitable example along with structure.
05

(c) Define Drug Therapy. Write a note on history of medicinal chemistry
05



Q. 6 (a) What is Phase ? I metabolism? Discuss in detail Oxidative biotransformation.
06

(b) Write a note on Prokinetics.
05

(c) Discuss SAR of Parasympathomimetics.
05



Q.7 (a) Write a short note on : a) Decongestants b) Respiratory Stimulants
06
OR

(a) Discuss in depth eicosanoids approved for human clinical use.
06
OR

(a) Give the synthesis of Cetrizine and Neostigmine.
06
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