Download GTU B.Pharma 2020 Summer 4th Sem BP402TP Medicinal Chemistry I Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Summer 4th Sem BP402TP Medicinal Chemistry I Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. - SEMESTER?IV ? EXAMINATION ? SUMMER -2020
Subject Code: BP402TP
Date: 27-10-2020
Subject Name: Medicinal Chemistry I
Time: 10:30 AM TO 1:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Write all possible routes for the metabolism of norepinephrine.
06

(b) Write the biosynthesis of norepinephrine with chemical reactions.
05

(c) Discuss the types of cholinergic receptors with their distribution.
05



Q.2 (a) Describe the SAR of adrenergic agonists.
06

(b) Write a note on indirectly acting sympathomimetics.
05

(c) Write the synthesis of salbutamol and propranolol.
05



Q.3 (a) Discuss in brief the development of medicinal chemistry.
06

(b) Make an introductory note on phase I and phase II metabolism.
05

(c) Discuss the importance of protein binding and hydrogen bonding in producing 05
drug's biological action.



Q.4 (a) Classify the antiepileptics with one drug's structure from each class.
06

(b) Discuss the structural modifications of 5-phenyl-1,4-benzodiazepin-2-one.
05

(c) Write the synthesis of any two anticonvulsant drugs.
05



Q.5 (a) Define the word `opioids'. Write the name and structures of narcotic 06
antagonists.

(b) Write the mechanism of action of NSAIDs. Write the synthesis of any one 05
NSAID from aryl propionic acid class.

(c) Classify the NSAIDs with one drug's structure from each class.
05



Q. 6 (a) Define neuroleptics. Write the mechanism of action and possible side effects of 06
them.

(b) Describe the structural modification of side chain of phenothiazines.
05

(c) Classify the general anaesthetics with two drugs' structures from each class.
05



Q.7 (a) Classify the parasympathomimetics with two drugs' structures from each class.
06

(b) Write a note on cholinesterase reactivators.
05

(c) Write the chemical class, synthesis and use of dicyclomine hydrochloride.
05
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